dc.creator | Sánchez Ramón, Silvia | es |
dc.creator | Bermúdez, Arancha | es |
dc.creator | González Granado, Luis Ignacio | es |
dc.creator | Rodríguez Gallego, Carlos | es |
dc.creator | Sastre, Ana | es |
dc.creator | Soler Palacín, Pere | es |
dc.creator | ID Signal Oncohaematology Grp | es |
dc.creator | Olbrich, Peter | es |
dc.date.accessioned | 2024-05-21T15:03:15Z | |
dc.date.available | 2024-05-21T15:03:15Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Sánchez Ramón, S., Bermúdez, A., González Granado, L.I., Rodríguez Gallego, C., Sastre, A., Soler Palacín, P.,...,Olbrich, P. (2019). Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management. Frontiers In Immunology, 10 (Mar), 586. https://doi.org/10.3389/fimmu.2019.00586. | |
dc.identifier.issn | 1664-3224 | es |
dc.identifier.uri | https://hdl.handle.net/11441/158766 | |
dc.description.abstract | Background: Immunodeficiencies (ID), in particular primary immunodeficiencies (PID),
are often associated with haematological manifestations, such as peripheral cytopenias
or lymphoproliferative syndromes. Early diagnosis and management have significant
prognostic implications. Secondary immunodeficiencies (SID) may also be induced by
oncohaematological diseases and their treatments. Haematologists and oncologists
must therefore be aware of the association between blood disorders and cancer and
ID, and be prepared to offer their patients appropriate treatment without delay. Our aim
was to define the warning signs of primary and secondary IDs in paediatric and adult
patients with oncohaematological manifestations.
Methods: A multidisciplinary group of six experts (2 haematologists, 2 immunologists,
and 2 paediatricians specializing in ID) conducted a literature review and prepared a
document based on agreements reached an in-person meeting. An external group of 44
IDs specialists from all over Spain assessed the document and were consulted regarding
their level of agreement.
Results: This document identifies the haematological and extra-haematological
diseases that should prompt a suspicion of PIDs in adults and children, in both
primary care and haematology and oncology departments. Cytopenia and certain
lymphoproliferative disorders are key diagnostic pointers. The diagnosis must be based
on a detailed clinical history, physical exploration, complete blood count and standard
laboratory tests. The immunological and haematological tests included in the diagnostic
process will depend on the care level. Patients who are candidates for immunoglobulin
replacement therapy must be carefully selected, and treatment should be offered as
soon as possible to avoid the development of complications. Finally, this document
recommends procedures for monitoring these patients.
Conclusions: This document combines scientific evidence with the opinion of a
broad panel of experts, and emphasizes the importance of an early diagnosis and treatment to avoid complications. The resulting document is a useful tool for primary
care physicians and specialists who see both adult and paediatric patients with
oncohaematological diseases. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media S.A. | es |
dc.relation.ispartof | Frontiers In Immunology, 10 (Mar), 586. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Immunoglobulins/deficiency | es |
dc.subject | Antibodies/deficiency | es |
dc.subject | Immunoglobulins/administration and dosage | es |
dc.subject | Autoimmunity | es |
dc.subject | Hematologic neoplasms | es |
dc.subject | Immunologic deficiency syndromes | es |
dc.title | Primary and Secondary Immunodeficiency Diseases in Oncohaematology: Warning Signs, Diagnosis, and Management | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología | es |
dc.relation.publisherversion | https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00586/full | es |
dc.identifier.doi | 10.3389/fimmu.2019.00586 | es |
dc.journaltitle | Frontiers In Immunology | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | Mar | es |
dc.publication.initialPage | 586 | es |