dc.creator | Mendia, Irati | es |
dc.creator | Segura Montero, Verónica | es |
dc.creator | Ruiz Carnicer, Ángela | es |
dc.creator | Coto, Laura | es |
dc.creator | Negrete, María | es |
dc.creator | Long, Joshua C. D. | es |
dc.creator | Comino Montilla, Isabel María | es |
dc.creator | Sousa Martín, Carolina | es |
dc.date.accessioned | 2024-04-22T11:28:09Z | |
dc.date.available | 2024-04-22T11:28:09Z | |
dc.date.issued | 2023-11-26 | |
dc.identifier.citation | Mendia, I., Segura Montero, V., Ruiz Carnicer, Á., Coto, L., Negrete, M., Long, J.C.D.,...,Sousa Martín, C. (2023). Rapid Anti-tTG-IgA Screening Test for Early Diagnosis of Celiac Disease in Pediatric Populations. Nutrients, 15 (23), 4926. https://doi.org/10.3390/nu15234926. | |
dc.identifier.issn | 2072-6643 | es |
dc.identifier.uri | https://hdl.handle.net/11441/156956 | |
dc.description.abstract | A large number of patients with celiac disease (CD) remain undiagnosed because they do
not fulfill the criteria for entry into the conventional diagnostic workflow. This study evaluated the
clinical utility of anti-tissue transglutaminase IgA antibody lateral flow immunoassays (anti-tTG-IgA
LFIA) in the undiagnosed-CD-based pediatric population and the impact of a gluten-free diet (GFD)
on screening-detected CD. A total of 576 volunteers were tested for anti-tTG-IgA. Gluten consumption
habits, CD related symptoms, and risk factors for CD development were evaluated. Volunteers testing
positive for anti-tTG-IgA were referred to the conventional CD diagnostic workflow, and the impact of
the GFD on health-related quality of life (HR-QoL) was measured. Among them, 13 had a positive antitTG-IgA LFIA test result: 11 had confirmed CD (1.91%), one refused confirmatory tests, and another
is undergoing diagnosis. Regarding the CD prevalence, no significant differences were observed
among risk (1.89%) and symptomatic (2.65%) groups and the entire tested population (1.55%). Rapid
anti-tTG-IgA LFIAs could be of clinical utility in primary care for the early identification of children
with CD unidentified by the conventional diagnostic workflow. It could potentially reduce the costs
of undiagnosed CD, avoiding unnecessary referrals to gastroenterologists, reducing diagnosis delays
and long-term problems, and improving patients’ HR-QoL. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación de España DI-17-096274 | es |
dc.description.sponsorship | Fondos RETOS de la Agenicia Estatal de investigación de España RTC2019-006806-1 | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Nutrients, 15 (23), 4926. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | celiac disease diagnosis | es |
dc.subject | gluten intake | es |
dc.subject | anti-tTG-IgA | es |
dc.subject | PoCT | es |
dc.subject | LFIA | es |
dc.title | Rapid Anti-tTG-IgA Screening Test for Early Diagnosis of Celiac Disease in Pediatric Populations | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología y Parasitología | es |
dc.relation.projectID | DI-17-096274 | es |
dc.relation.projectID | RTC2019-006806-1 | es |
dc.relation.publisherversion | https://doi.org/10.3390/nu15234926 | es |
dc.identifier.doi | 10.3390/nu15234926 | es |
dc.journaltitle | Nutrients | es |
dc.publication.volumen | 15 | es |
dc.publication.issue | 23 | es |
dc.publication.initialPage | 4926 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |