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dc.creatorAguilar de Leyva, Mercedes Ángelaes
dc.creatorCasas Delgado, Martaes
dc.creatorFerrero Rodríguez, Carmenes
dc.creatorLinares Blasco, Vicentees
dc.creatorCaraballo Rodríguez, Isidoroes
dc.date.accessioned2024-04-01T11:34:50Z
dc.date.available2024-04-01T11:34:50Z
dc.date.issued2024-03-22
dc.identifier.citationAguilar de Leyva, M.Á., Casas Delgado, M., Ferrero Rodríguez, C., Linares Blasco, V. y Caraballo Rodríguez, I. (2024). 3D Printing DirePowder Extrusion in the Production of Drug Delivery Systems: State of the Art and Future Perspectives. Pharmaceutics, 16 (4), 437. https://doi.org/10.3390/pharmaceutics16040437.
dc.identifier.issn1999-4923es
dc.identifier.urihttps://hdl.handle.net/11441/156572
dc.description.abstractThe production of tailored, on-demand drug delivery systems has gained attention in pharmaceutical development over the last few years, thanks to the application of 3D printing technology in the pharmaceutical field. Recently, direct powder extrusion (DPE) has emerged among the extrusion-based additive manufacturing techniques. It is a one-step procedure that allows the direct processing of powdered formulations. The aim of this systematic literature review is to analyze the production of drug delivery systems using DPE. A total of 27 articles have been identified through scientific databases (Scopus, PubMed, and ScienceDirect). The main characteristics of the three types of 3D printers based on DPE have been discussed. The selection of polymers and auxiliary excipients, as well as the flowability of the powder mixture, the rheological properties of the molten material, and the printing temperatures have been identified as the main critical parameters for successful printing. A wide range of drug delivery systems with varied geometries and different drug release profiles intended for oral, buccal, parenteral, and transdermal routes have been produced. The ability of this technique to manufacture personalized, on-demand drug delivery systems has been proven. For all these reasons, its implementation in hospital settings in the near future seems promising.es
dc.description.sponsorshipConsejería de Economía, Conocimiento, Empresas y Universidad (Junta de Andalucía, España) y FEDER 2014-2020 US-1380923es
dc.formatapplication/pdfes
dc.format.extent26 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofPharmaceutics, 16 (4), 437.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject3D printinges
dc.subjectdirect powder extrusiones
dc.subjectrheological propertieses
dc.subjectdrug delivery systemses
dc.subjectpersonalized medicinees
dc.title3D Printing DirePowder Extrusion in the Production of Drug Delivery Systems: State of the Art and Future Perspectiveses
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéuticaes
dc.relation.projectIDUS-1380923es
dc.relation.publisherversionhttps://doi.org/10.3390/pharmaceutics16040437es
dc.identifier.doi10.3390/pharmaceutics16040437es
dc.journaltitlePharmaceuticses
dc.publication.volumen16es
dc.publication.issue4es
dc.publication.initialPage437es
dc.contributor.funderJunta de Andalucíaes
dc.contributor.funderEuropean Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER)es

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