Artículo
Graphene-coated Ti-Nb-Ta-Mn foams: A promising approach towards a suitable biomaterial for bone replacement
Autor/es | Lascano, Sheila
Chávez-Vásconez Ricardo Muñoz-Rojas, Daniela Reyes-Valenzuela, Mauricio Arévalo Mora, Cristina María Torres Hernández, Yadir |
Departamento | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte |
Fecha de publicación | 2020-11 |
Fecha de depósito | 2024-02-08 |
Publicado en |
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Resumen | The design of bone implants with proper biological and mechanical properties remains a challenge in medical implantology. The use of bioactive coatings has been shown to improve the biocompatibility of the implant surface. ... The design of bone implants with proper biological and mechanical properties remains a challenge in medical implantology. The use of bioactive coatings has been shown to improve the biocompatibility of the implant surface. In this study, a new approach including porous scaffolds, β-Ti alloys and nanocoatings to design new bone implants is presented. Porous Ti-Nb-Ta-xMn alloys (x: 2, 4, and 6 wt%) substrates were obtained by powder metallurgy and the effect of the porosity and Mn content on mechanical properties was studied. CVD single-layer graphene was transferred onto the porous substrates that presented the best mechanical response (x: 4 wt%) for further evaluation of in vitro cell behavior (biocompatibility and cell adhesion). Cytotoxicity and biocompatibility tests confirmed that cell adhesion and proliferation were successfully achieved on graphene-coated porous substrates, confirming these systems are potential candidates for using in partial bone tissue replacement. © 2020 Elsevier B.V. |
Agencias financiadoras | Universidad de Sevilla |
Cita | Lascano, S., Chávez-Vásconez Ricardo, , Muñoz-Rojas, D., Reyes-Valenzuela, M.,..., Arévalo, C. y Torres, Y. (2020). Graphene-coated Ti-Nb-Ta-Mn foams: A promising approach towards a suitable biomaterial for bone replacement. Surface and Coatings Technology, 401, 126250. https://doi.org/10.1016/j.surfcoat.2020.126250. |
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