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dc.creatorBorroni, Davidees
dc.creatorMazzotta, Cosimoes
dc.creatorRocha de Lossada, Carloses
dc.creatorSánchez González, José Maríaes
dc.creatorBallesteros Sánchez, Antonioes
dc.creatorGarcía Lorente, Maríaes
dc.creatorZamorano Martín, Franciscoes
dc.creatorSpinelli, Antonioes
dc.creatorSchiano Lomoriello, Domenicoes
dc.creatorTedesco, Giovanni Robertoes
dc.date.accessioned2024-02-07T17:21:41Z
dc.date.available2024-02-07T17:21:41Z
dc.date.issued2023
dc.identifier.citationBorroni, D., Mazzotta, C., Rocha de Lossada, C., Sánchez González, J.M., Ballesteros Sánchez, A., García Lorente, M.,...,Tedesco, G.R. (2023). Dry Eye Para-Inflammation Treatment: Evaluation of a Novel Tear Substitute Containing Hyaluronic Acid and Low-Dose Hydrocortisone. Biomedicines, 11 (12), 3277. https://doi.org/10.3390/biomedicines11123277.
dc.identifier.issn2227-9059es
dc.identifier.urihttps://hdl.handle.net/11441/154848
dc.description.abstractPurpose: The purpose of this study was to check the efficacy and safety of a novel tear substitute containing hyaluronic acid and low-dose hydrocortisone in the treatment of moderate dry eye disease. Methods: In this prospective randomized study, 38 patients with moderate dry eye disease were divided into two treatment groups: Group 1 received one drop of 0.2% sodium hyaluronate and 0.001% hydrocortisone four times daily for 3 months, while Group 2 received 0.15% sodium hyaluronate and 3% trehalose at the same dosage. OSDI and SANDE questionnaires, Non-Invasive Break-Up time (NIBUT), Tear Meniscus Height (TMH), meibography, Lipid Layer Thickness (LLT), Tear Break-Up Time (TBUT), Corneal Staining Score (CFS), and Intraocular Pressure (IOP) were evaluated at baseline and after 1, 2, and 3 months of treatment. Results: During the treatment period, Group 1 showed statistically significant improvement in OSDI score (p = 0.002), SANDE score (p = 0.01), NIBUT (p < 0.0001), LLT (p < 0.0001), TBUT (p = 0.01), and CFS (p = 0.02). In Group 2, significant improvement was observed only in the TBUT score (p < 0.05). Comparison of the two groups showed that NIBUT and LLT were significantly different at the end of treatment (p = 0.001 for both comparisons), with more favorable results for sodium hyaluronate and hydrocortisone than for sodium hyaluronate and trehalose. No significant variations in intraocular pressure were observed in either group during the treatment period (p > 0.05). Conclusions: The study confirms that a 3-months treatment with hyaluronic acid 0.2% in combination with low-dose hydrocortisone 0.001% improves the signs and symptoms of moderate DED and that a low-dosage 0.001% hydrocortisone can be helpful in preventing the progression to chronic stages of DED.es
dc.formatapplication/pdfes
dc.format.extent10 p.es
dc.language.isoenges
dc.publisherMDPIes
dc.relation.ispartofBiomedicines, 11 (12), 3277.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCorticosteroidses
dc.subjectDry eye diseasees
dc.subjectHyaluronic acides
dc.subjectHydrocortisonees
dc.subjectParainflammationes
dc.titleDry Eye Para-Inflammation Treatment: Evaluation of a Novel Tear Substitute Containing Hyaluronic Acid and Low-Dose Hydrocortisonees
dc.typeinfo:eu-repo/semantics/articlees
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Física de la Materia Condensadaes
dc.relation.publisherversionhttps://doi.org/10.3390/biomedicines11123277es
dc.identifier.doi10.3390/biomedicines11123277es
dc.journaltitleBiomedicineses
dc.publication.volumen11es
dc.publication.issue12es
dc.publication.initialPage3277es

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