dc.creator | Caro Magdaleno, Manuel | es |
dc.creator | Alfaro-Juarez, Asunción | es |
dc.creator | Montero Iruzubieta, Jesús | es |
dc.creator | Fernández Palacín, Ana | es |
dc.creator | Muñoz Morales, Ana | es |
dc.creator | Castilla Martino, Manuel Alberto | es |
dc.creator | Spínola Muñoz, Consuelo | es |
dc.creator | Rodríguez-de-la-Rúa, Enrique | es |
dc.date.accessioned | 2024-02-01T13:20:18Z | |
dc.date.available | 2024-02-01T13:20:18Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Caro Magdaleno, M., Alfaro-Juarez, A., Montero Iruzubieta, J., Fernández Palacín, A., Muñoz Morales, A., Castilla Martino, M.A.,...,Rodríguez-de-la-Rúa, E. (2019). In vivo confocal microscopy indicates an inverse relationship between the sub-basal corneal plexus and the conjunctivalisation in patients with limbal stem cell deficiency. British Journal of Ophthalmology, 103 (3), 327-331. https://doi.org/10.1136/bjophthalmol-2017-311693. | |
dc.identifier.issn | 0007-1161 | es |
dc.identifier.issn | 1468-2079 | es |
dc.identifier.uri | https://hdl.handle.net/11441/154425 | |
dc.description.abstract | Background/aims: Limbal stem cell deficiency (LSCD) is characterised by a marked decrease in limbal stem cells. It is classified primarily using subjective slit-lamp observations. In vivo confocal microscopy (IVCM) can non-invasively provide objective information on the condition of the limbal niche, the corneal epithelial basal cell density and the corneal sub-basal nerve plexus density (SND). We here used IVCM to evaluate changes in SND to improve LSCD classification.
Methods: We evaluated and classified 38 patients (76 eyes, 44 with LSC and 32 control eyes) using the Rama, López-García and Deng (clinical and confocal) classifications and evaluated the concordance of the confocal and clinical classifications. We constructed a logistic regression model using multivariate analysis to correlate different degrees of conjunctivalisation with IVCM parameters and used receiver operating characteristic (ROC) curve analysis to establish the SND cut-off value with maximum diagnostic sensitivity and specificity.
Results: The classification systems correlated moderately at best (kappa, 0.449). The corneal SND of cases (6469±6295 µm/mm2) was less (p<0.001) than in controls (20911±4142 µm/mm2). The SND, but not basal cell density, played a protective role against conjunctivalisation (OR, 0.069; 95% CI 0.008–0.619; p=0.01). An SND cut-off value of 17 215 µm/mm2 yielded a sensitivity and specificity of 95.5% and 90.6%, respectively, for LSCD diagnosis.
Conclusion: The density of the corneal sub-basal nerve plexus was inversely related to conjunctivalisation in LSCD. Further studies are needed to verify this and to elucidate the directionality between these factors. | es |
dc.description.sponsorship | European Union (FEDER/FSE) \'Una manera de hacer Europa\' | es |
dc.description.sponsorship | Iniciativa Andaluza en Terapias Avanzadas (IATA) | es |
dc.description.sponsorship | Instituto de Salud Carlos III, as part of the Plan Nacional I+D+i 2013-2016 RD16/0008/0010 | es |
dc.description.sponsorship | RETICS OFTARED | es |
dc.format | application/pdf | es |
dc.format.extent | 5 | es |
dc.language.iso | eng | es |
dc.publisher | BMJ Journals | es |
dc.relation.ispartof | British Journal of Ophthalmology, 103 (3), 327-331. | |
dc.rights | Atribución-NoComercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Limbal stem cell deficiency (LSCD) | es |
dc.subject | In vivo confocal microscopy (IVCM) | es |
dc.subject | Corneal sub-basal nerve plexus density (SND) | es |
dc.title | In vivo confocal microscopy indicates an inverse relationship between the sub-basal corneal plexus and the conjunctivalisation in patients with limbal stem cell deficiency | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública | es |
dc.relation.publisherversion | https://bjo.bmj.com/content/103/3/327 | es |
dc.identifier.doi | 10.1136/bjophthalmol-2017-311693 | es |
dc.contributor.group | Universidad de Sevilla. CTS-312: Análisis de la Demanda Sanitaria | es |
dc.journaltitle | British Journal of Ophthalmology | es |
dc.publication.volumen | 103 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 327 | es |
dc.publication.endPage | 331 | es |
dc.description.awardwinning | | |
dc.description.awardwinning | Premio Anual Publicación Científica Destacada de la US. Facultad de Medicina | |