dc.creator | Azorín-Ortuño, María | es |
dc.creator | Yáñez-Gascón, María J. | es |
dc.creator | Vallejo, Fernando | es |
dc.creator | Pallarés, Francisco J. | es |
dc.creator | Larrosa, Mar | es |
dc.creator | Lucas Rodríguez, Ricardo | es |
dc.creator | Morales, Juan C. | es |
dc.creator | Tomás-Barberán, Francisco A. | es |
dc.creator | García-Conesa, María T. | es |
dc.creator | Espín, Juan C. | es |
dc.date.accessioned | 2024-01-31T18:19:45Z | |
dc.date.available | 2024-01-31T18:19:45Z | |
dc.date.issued | 2011-08 | |
dc.identifier.citation | Azorín-Ortuño, M., Yáñez-Gascón, M.J., Vallejo, F., Pallarés, F.J., Larrosa, M., Lucas Rodríguez, R.,...,Espín, J.C. (2011). Metabolites and tissue distribution of resveratrol in the pig. Molecular Nutrition and Food Research, 55 (8), 1154-1168. https://doi.org/10.1002/mnfr.201100140. | |
dc.identifier.issn | 1613-4125 | es |
dc.identifier.issn | 1613-4133 | es |
dc.identifier.uri | https://hdl.handle.net/11441/154367 | |
dc.description.abstract | Scope: trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism and tissue distribution of RES using the pig, a mammal physiologically close to humans. Methods and results: Forty-seven tissues, organs and fluids were analyzed 6h after intragastric RES administration (5.9mg/kg body weight) using HPLC-MS/MS. Twelve RES and seven dihydroresveratrol (DH-RES) metabolites were detected. DH-RES was the main metabolite in cecum, colon and rectum, whereas RES-3-O-glucuronide was the most abundant one in fluids and organs. Approximately 74.5% of the total RES administered was recovered in the form of RES, DH-RES and derived metabolites (65.1% along the gastrointestinal tract, 7.7% in urine, 1.2% in bile and 0.5% in organs). We report here, for the first time, the occurrence of RES ribosyl-sulfate derivative, DH-RES diglucuronide, DH-RES sulfoglucuronide and DH-RES disulfate as well as the metabolic profile of RES and DH-RES in the aorta, lymph, lymph node, ovaries, uterus, cerebellum, pancreas, urinary bladder tissue, fat and muscle. Conclusion: This study contributes to the clarification of the metabolism and tissue distribution of RES and could help to further understand the mechanisms underlying its effects. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación CICYT-BFU2007-60576, CSD2007-00063 | es |
dc.description.sponsorship | Comunidad Autónoma de Murcia 04486 | es |
dc.format | application/pdf | es |
dc.format.extent | 34 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Blackwell | es |
dc.relation.ispartof | Molecular Nutrition and Food Research, 55 (8), 1154-1168. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Bioavailability | es |
dc.subject | Dihydroresveratrol | es |
dc.subject | Disposition | es |
dc.subject | Metabolites | es |
dc.subject | Polyphenol | es |
dc.title | Metabolites and tissue distribution of resveratrol in the pig | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.relation.projectID | CICYT-BFU2007-60576 | es |
dc.relation.projectID | CSD2007-00063 | es |
dc.relation.projectID | 04486 | es |
dc.relation.publisherversion | https://doi.org/10.1002/mnfr.201100140 | es |
dc.identifier.doi | 10.1002/mnfr.201100140 | es |
dc.journaltitle | Molecular Nutrition and Food Research | es |
dc.publication.volumen | 55 | es |
dc.publication.issue | 8 | es |
dc.publication.initialPage | 1154 | es |
dc.publication.endPage | 1168 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Comunidad Autónoma de Murcia | es |