dc.creator | Benito Hernández, Elena María | es |
dc.creator | Romero Azogil, Lucía | es |
dc.creator | Galbis Fuster, Elsa | es |
dc.creator | Paz Báñez, María Violante de | es |
dc.creator | García Martín, María de Gracia | es |
dc.date.accessioned | 2024-01-26T08:56:13Z | |
dc.date.available | 2024-01-26T08:56:13Z | |
dc.date.issued | 2020-08-15 | |
dc.identifier.citation | Benito Hernández, E.M., Romero Azogil, L., Galbis Fuster, E., Paz Báñez, M.V.d. y García Martín, M.d.G. (2020). Structurally simple redox polymersomes for doxorubicin delivery. European Polymer Journal, 137, 109952. https://doi.org/10.1016/j.eurpolymj.2020.109952. | |
dc.identifier.issn | 0014-3057 | es |
dc.identifier.issn | 1873-1945 | es |
dc.identifier.uri | https://hdl.handle.net/11441/154051 | |
dc.description.abstract | A simple redox amphiphilic tri-block copolyurethane capable of assembling in the form of polymersome has been easily
synthesized. Thus, the hydrophobic core is constituted by a central block containing multiple disulfide linkages, and the
hydrophilic segments are formed by poly(ethylene glycol) methyl ether (mPEG2000). The disulfide-containing block was
obtained by the reaction of commercial 2,2′-dithiodiethanol and hexamethylene diisocyanate, which was further reacted with the mentioned PEG to afford the tri-block copolymer nominated as mPEG-PDH-mPEG, in above 80% yield.
This copolymer self-assembled into polymersomes of size around 130 nm by the water addition/solvent evaporation
method. Different systems of doxorubicin/polymer ratios (D/P 0.5 – 3) were prepared and the drug loading (%DL) and
encapsulation efficiency (%EE) were studied by visible light absorbance measurements. Systems D/P 2 and 3 showed
DL up to 62% and 69%, respectively. Besides that, D/P 1 and 2 presented EE values in the order of 83%. Finally, the
release of DOX in the presence of 0.01 M glutathione solutions at 37 °C, was 74.6% and 82% from D/P 3 and D/P 0.5,
respectively, after 5 days of incubation. Further studies on other water-soluble drugs for the cancer treatment would be
of great interest to demonstrate the high potential of these redox polymeric systems. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad de España - MAT2016-77345-C3-2-P | es |
dc.description.sponsorship | Junta de Andalucía - P12-FQM-1553 | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | European Polymer Journal, 137, 109952. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Stimuli-responsive polymersomes | es |
dc.subject | Copolyurethanes | es |
dc.subject | Redox-sensitive systems | es |
dc.subject | Doxorubicin | es |
dc.subject | Drug loading | es |
dc.subject | Drug delivery systems | es |
dc.title | Structurally simple redox polymersomes for doxorubicin delivery | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.relation.projectID | MAT2016-77345-C3-2-P | es |
dc.relation.projectID | P12-FQM-1553 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.eurpolymj.2020.109952 | es |
dc.identifier.doi | 10.1016/j.eurpolymj.2020.109952 | es |
dc.journaltitle | European Polymer Journal | es |
dc.publication.volumen | 137 | es |
dc.publication.initialPage | 109952 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Junta de Andalucía | es |