Artículo
Model of dissolution in the framework of tissue engineering and drug delivery
Autor/es | Sanz Herrera, José Antonio
Soria Conde, Laureano Reina Romo, Esther Torres Hernández, Yadir Boccaccini, Aldo R. |
Departamento | Universidad de Sevilla. Departamento de Mecánica de Medios Continuos y Teoría de Estructuras Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte |
Fecha de publicación | 2018-10 |
Fecha de depósito | 2024-01-15 |
Publicado en |
|
Resumen | Dissolution phenomena are ubiquitously present in biomaterials in many different fields. Despite the advantages of simulation-based design of biomaterials in medical applications, additional efforts are needed to derive ... Dissolution phenomena are ubiquitously present in biomaterials in many different fields. Despite the advantages of simulation-based design of biomaterials in medical applications, additional efforts are needed to derive reliable models which describe the process of dissolution. A phenomenologically based model, available for simulation of dissolution in biomaterials, is introduced in this paper. The model turns into a set of reaction–diffusion equations implemented in a finite element numerical framework. First, a parametric analysis is conducted in order to explore the role of model parameters on the overall dissolution process. Then, the model is calibrated and validated versus a straightforward but rigorous experimental setup. Results show that the mathematical model macroscopically reproduces the main physicochemical phenomena that take place in the tests, corroborating its usefulness for design of biomaterials in the tissue engineering and drug delivery research areas. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España |
Identificador del proyecto | MAT2015-71284-P |
Cita | Sanz-Herrera, J.A., Soria Conde, L., Reina-Romo, E., Torres, Y. y Boccaccini, A.R. (2018). Model of dissolution in the framework of tissue engineering and drug delivery. Biomechanics and Modeling in Mechanobiology, 17 (5), 1331-1341. https://doi.org/10.1007/s10237-018-1029-4. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
BMM_2018_Sanz-Herrera_Model_po ... | 2.006Mb | [PDF] | Ver/ | Versión aceptada |