dc.creator | Pozo Torres, Esther | es |
dc.creator | Caro Salazar, Carlos | es |
dc.creator | Páez-Muñoz, José María | es |
dc.creator | García-Martín, María Luisa | es |
dc.creator | Fernández Fernández, Inmaculada | es |
dc.creator | Pernia Leal, Manuel | es |
dc.date.accessioned | 2024-01-12T12:28:51Z | |
dc.date.available | 2024-01-12T12:28:51Z | |
dc.date.issued | 2020-03-05 | |
dc.identifier.citation | Pozo Torres, E., Caro Salazar, C., Páez-Muñoz, J.M., García-Martín, M.L., Fernández Fernández, I. y Pernia Leal, M. (2020). Clickable iron oxide NPs based on catechol derived ligands: synthesis and characterization. Soft Materials, 16 (13), 3257-3266. https://doi.org/10.1039/C9SM02512J. | |
dc.identifier.issn | 1744-683X | es |
dc.identifier.issn | 1744-6848 | es |
dc.identifier.uri | https://hdl.handle.net/11441/153293 | |
dc.description.abstract | Clickable magnetic nanoparticles have attracted great attention as potential nanoplatforms for biomedical
applications because of the high functionalization efficiency of their surfaces with biomolecules, which
facilitates their bio-compatibilization. However, the design and synthesis of clickable NPs is still
challenging because of the complexity of the chemistry on the magnetic NP surface, thus robust
methods that improve the ligand synthesis and the transfer of magnetic NPs in physiological media being
in high-demand. In this work, we developed a versatile and enhanced synthetic route to fabricate
potentially clickable IONPs of interest in nanomedicine. Catechol anchor ligands with different stereoelectronic features were synthetized from a hetero bi-functional PEG spacer backbone. The resulting
catechol ligands transferred in good yields and high stability to magnetic NPs by an improved energetic
ligand exchange method that combines sonication and high temperature. The azido functionalized IONPs
exhibited excellent characteristics as T2 MRI contrast agents with low cytotoxicity, making these clickable
magnetic NPs promising precursors for nanomedicines. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad de España - CTQ2017-86655-R a MPL y MLGM; CTQ2016-78580-C2-2-R a IFF | es |
dc.description.sponsorship | Universidad de Sevilla - VI PPIT y V PPIT | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Taylor and Francis Group | es |
dc.relation.ispartof | Soft Materials, 16 (13), 3257-3266. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Clickable iron oxide NPs based on catechol derived ligands: synthesis and characterization | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.relation.projectID | CTQ2017-86655-R | es |
dc.relation.projectID | CTQ2016-78580-C2-2-R | es |
dc.relation.projectID | USE VI PPIT | es |
dc.relation.projectID | USE V PPIT | es |
dc.relation.publisherversion | DOI https://doi.org/10.1039/C9SM02512J | es |
dc.identifier.doi | 10.1039/C9SM02512J | es |
dc.journaltitle | Soft Materials | es |
dc.publication.volumen | 16 | es |
dc.publication.issue | 13 | es |
dc.publication.initialPage | 3257 | es |
dc.publication.endPage | 3266 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Universidad de Sevilla | es |