dc.creator | Caro Salazar, Carlos | es |
dc.creator | Páez-Muñoz, José María | es |
dc.creator | Beltrán, Ana M. | es |
dc.creator | Pernia Leal, Manuel | es |
dc.creator | García-Martín, María Luisa | es |
dc.date.accessioned | 2024-01-10T15:51:54Z | |
dc.date.available | 2024-01-10T15:51:54Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Caro Salazar, C., Páez-Muñoz, J.M., Beltrán, A.M., Pernía Leal, M. y García Martín, M.L. (2021). PEGylated Terbium-Based Nanorods as Multimodal Bioimaging Contrast Agents. ACS Applied Nano Materials, 4 (4), 4199-4207. https://doi.org/10.1021/acsanm.1c00569. | |
dc.identifier.issn | 2574-0970 | es |
dc.identifier.uri | https://hdl.handle.net/11441/153184 | |
dc.description.abstract | Diagnostic imaging strongly relies on the use of contrast agents (CAs). In general terms, current CAs present undesirable side effects that encourage researchers and pharmaceutical companies to continually search for safer and more versatile alternatives. Here, we describe the synthesis and characterization of terbium-based nanorods (TbNRs) as a potential alternative to traditional CAs for magnetic resonance imaging (MRI) and X-ray computed tomography (CT). The paramagnetism and high atomic number of Tb provide TbNRs with both magnetic relaxivity and X-ray attenuation capabilities. After surface functionalization with a polyethylene glycol (PEG)-derived ligand, TbNRs showed high colloidal stability in physiological media. Additionally, toxicity studies conducted in cell cultures and zebrafish embryos demonstrated the safety of the as-synthesized TbNRs, thus supporting their potential use as CAs. Lastly, in vivo imaging experiments in mice demonstrated that TbNRs produce remarkable contrast enhancement on both MRI and CT. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad CTQ2017-86655-R | es |
dc.description.sponsorship | Junta de Andalucía OH-0026-2018, PI2013-0559 | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | American Chemical Society | es |
dc.relation.ispartof | ACS Applied Nano Materials, 4 (4), 4199-4207. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Contrast agents | es |
dc.subject | CT | es |
dc.subject | MRI | es |
dc.subject | Multimodal imaging | es |
dc.subject | Rare-earth nanoparticles | es |
dc.subject | Terbium | es |
dc.title | PEGylated Terbium-Based Nanorods as Multimodal Bioimaging Contrast Agents | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte | es |
dc.relation.projectID | CTQ2017-86655-R | es |
dc.relation.projectID | OH-0026-2018 | es |
dc.relation.projectID | PI2013-0559 | es |
dc.relation.publisherversion | https://dx.doi.org/10.1021/acsanm.1c00569 | es |
dc.identifier.doi | 10.1021/acsanm.1c00569 | es |
dc.journaltitle | ACS Applied Nano Materials | es |
dc.publication.volumen | 4 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 4199 | es |
dc.publication.endPage | 4207 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.contributor.funder | Junta de Andalucía | es |