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Biosynthetic gene profiling and genomic potential of the novel photosynthetic marine bacterium Roseibaca domitiana
dc.creator | Gattoni, Giuliano | es |
dc.creator | Di Costanzo, Fabiana | es |
dc.creator | Ruiz de la Haba, Rafael | es |
dc.creator | Fernández, Ana B. | es |
dc.creator | Guerrero Flores, Shaday | es |
dc.creator | Selem Mojica, Nelly | es |
dc.creator | Ventosa Ucero, Antonio | es |
dc.creator | Corral, Paulina | es |
dc.date.accessioned | 2024-01-09T11:04:06Z | |
dc.date.available | 2024-01-09T11:04:06Z | |
dc.date.issued | 2023-09-29 | |
dc.identifier.citation | Gattoni, G., Di Costanzo, F., Ruiz de la Haba, R., Fernández, A.B., Guerrero Flores, S., Selem Mojica, N.,...,Corral, P. (2023). Biosynthetic gene profiling and genomic potential of the novel photosynthetic marine bacterium Roseibaca domitiana. Frontiers in Microbiology, 14, 1238779. https://doi.org/10.3389/fmicb.2023.1238779. | |
dc.identifier.issn | 1664-302X | es |
dc.identifier.uri | https://hdl.handle.net/11441/153068 | |
dc.description.abstract | Shifting the bioprospecting targets toward underexplored bacterial groups combined with genome mining studies contributes to avoiding the rediscovery of known compounds by revealing novel, promising biosynthetic gene clusters (BGCs). With the aim of determining the biosynthetic potential of a novel marine bacterium, strain V10T, isolated from the Domitian littoral in Italy, a comparative phylogenomic mining study was performed across related photosynthetic bacterial groups from an evolutionary perspective. Studies on polyphasic and taxogenomics showed that this bacterium constitutes a new species, designated Roseibaca domitiana sp. nov. To date, this genus has only one other validly described species, which was isolated from a hypersaline Antarctic lake. The genomic evolutionary study linked to BGC diversity revealed that there is a close relationship between the phylogenetic distance of the members of the photosynthetic genera Roseibaca, Roseinatronobacter, and Rhodobaca and their BGC profiles, whose conservation pattern allows discriminating between these genera. On the contrary, the rest of the species related to Roseibaca domitiana exhibited an individual species pattern unrelated to genome size or source of isolation. This study showed that photosynthetic strains possess a streamlined content of BGCs, of which 94.34% of the clusters with biotechnological interest (NRPS, PKS, RRE, and RiPP) are completely new. Among these stand out T1PKS, exclusive of R. domitiana V10T, and RRE, highly conserved only in R. domitiana V10T and R. ekhonensis, both categories of BGCs involved in the synthesis of plant growth-promoting compounds and antitumoral compounds, respectively. In all cases, with very low homology with already patented molecules. Our findings reveal the high biosynthetic potential of infrequently cultured bacterial groups, suggesting the need to redirect attention to microbial minorities as a novel and vast source of bioactive compounds still to be exploited. Copyright © 2023 Gattoni, Di Costanzo, de la Haba, Fernández, Guerrero-Flores, Selem-Mojica, Ventosa and Corral. | es |
dc.description.sponsorship | Fondazione CON IL SUD. Italia 2018-PDR-00533 | es |
dc.description.sponsorship | Universidad Autónoma de México (UNAM) PAPIIT IA103822 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación (MICIN). España PID2020-118136GB-I00 | es |
dc.description.sponsorship | Junta de Andalucía P20_01066, BIO-213 | es |
dc.description.sponsorship | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) P20_01066, BIO-213 | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media SA | es |
dc.relation.ispartof | Frontiers in Microbiology, 14, 1238779. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Bacteriochlorophyll | es |
dc.subject | Biosynthetic gene cluster (BGC) | es |
dc.subject | Biosynthetic profiling | es |
dc.subject | Genome mining | es |
dc.subject | Photosynthetic bacteria | es |
dc.subject | Roseibaca | es |
dc.title | Biosynthetic gene profiling and genomic potential of the novel photosynthetic marine bacterium Roseibaca domitiana | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología y Parasitología | es |
dc.relation.projectID | 2018-PDR-00533 | es |
dc.relation.projectID | PAPIIT IA103822 | es |
dc.relation.projectID | PID2020-118136GB-I00 | es |
dc.relation.projectID | P20_01066 | es |
dc.relation.projectID | BIO-213 | es |
dc.relation.publisherversion | https://doi.org/10.3389/fmicb.2023.1238779 | es |
dc.identifier.doi | 10.3389/fmicb.2023.1238779 | es |
dc.journaltitle | Frontiers in Microbiology | es |
dc.publication.volumen | 14 | es |
dc.publication.initialPage | 1238779 | es |
dc.contributor.funder | Fondazione CON IL SUD. Italia. | es |
dc.contributor.funder | Universidad Autónoma de México (UNAM) | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Junta de Andalucía | es |
dc.contributor.funder | European Commission (EC). Fondo Europeo de Desarrollo Regional (FEDER) | es |