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dc.creatorNaitlho, Nabilaes
dc.creatorRabasco Álvarez, Antonio Maríaes
dc.creatorPrieto Dapena, Franciscoes
dc.creatorRueda Rueda, Manuelaes
dc.creatorGonzález Rodríguez, María Luisaes
dc.date.accessioned2023-12-21T07:57:03Z
dc.date.available2023-12-21T07:57:03Z
dc.date.issued2019-08-20
dc.identifier.citationNaitlho, N., Rabasco Álvarez, A.M., Prieto Dapena, F., Rueda Rueda, M. y González Rodríguez, M.L. (2019). Didodecyldimethylammonium Bromide Role in Anchoring Gold Nanoparticles onto Liposome Surface for Triggering the Drug Release. AAPS PharmSciTech, 20 (7), 294. https://doi.org/10.1208/s12249-019-1492-y.
dc.identifier.issn1530-9932es
dc.identifier.urihttps://hdl.handle.net/11441/152749
dc.description.abstractLiposomes with their capacity to anchor gold nanoparticles (AuNPs) onto their surface are used in the treatment of several pathologies such as cancer. The objective of this work was the optimization of the vesicle composition by using cationic agents in order to reinforce the anchoring process of AuNPs, and for the study of the influence of local temperature and vesicle size on drug release. A Plackett–Burman design was conducted to determine the optimal composition for the anchoring of AuNPs. A comprehensive study of the influence of lipid bilayer composition on the surface charge, size, and polydispersity index (PdI) of liposomes was carried out. Afterwards, in vitro release studies by dialysis were performed and several release parameters were evaluated as a function of temperature. Cholesterol was fixed as the rigid agent and Didodecyldimethylammonium bromide (DDAB) was selected as the cationic lipid into the liposome bilayer. Photomicrographs revealed that DDAB facilitated the anchoring of AuNPs onto the liposomal surface. The anchoring of AuNPs also enhanced the amount and rate of calcein released, especially in extruded samples, at several incubating temperatures. In addition, it was observed that both the anchoring of AuNPs and the calcein release were improved by increasing the surface of the vesicles. The contributions of liposome composition (DDAB inclusion, incubation temperature, anchoring of AuNPs) and size and surface availability of the vesicles on calcein release could be used to design improved lipid nanostructures for the controlled release of anticancer drugs.es
dc.description.sponsorshipMinisterio de Economía y Competitividad CTQ2014-57515-C2-1-Res
dc.formatapplication/pdfes
dc.format.extent13 p.es
dc.language.isoenges
dc.publisherSpringeres
dc.relation.ispartofAAPS PharmSciTech, 20 (7), 294.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleDidodecyldimethylammonium Bromide Role in Anchoring Gold Nanoparticles onto Liposome Surface for Triggering the Drug Releasees
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Físicaes
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéuticaes
dc.relation.projectIDCTQ2014-57515-C2-1-Res
dc.relation.publisherversionhttps://dx.doi.org/10.1208/s12249-019-1492-yes
dc.identifier.doi10.1208/s12249-019-1492-yes
dc.contributor.groupUniversidad de Sevilla. FQM202: Electroquímica Fundamental y Aplicada a Farmaciaes
dc.contributor.groupUniversidad de Sevilla. CTS214: Sistemas de Liberación Controlada de Medicamentoses
dc.journaltitleAAPS PharmSciTeches
dc.publication.volumen20es
dc.publication.issue7es
dc.publication.initialPage294es
dc.contributor.funderMinisterio de Economía y Competitividad (MINECO). Españaes

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