Artículo
Elastic properties of woven bone: effect of mineral content and collagen fibrils orientation
Autor/es | García Rodríguez, Javier
Martínez Reina, Francisco Javier |
Departamento | Universidad de Sevilla. Departamento de Ingeniería Mecánica y de Fabricación |
Fecha de publicación | 2017 |
Fecha de depósito | 2023-11-27 |
Publicado en |
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Resumen | Woven bone is a type of tissue that forms mainly during fracture healing or fetal bone development. Its microstructure can be modeled as a composite with a matrix of mineral (hydroxyapatite) and inclusions of collagen ... Woven bone is a type of tissue that forms mainly during fracture healing or fetal bone development. Its microstructure can be modeled as a composite with a matrix of mineral (hydroxyapatite) and inclusions of collagen fibrils with a more or less random orientation. In the present study, its elastic properties were estimated as a function of composition (degree of mineralization) and fibril orientation. A self-consistent homogenization scheme considering randomness of inclusions’ orientation was used for this purpose. Lacuno-canalicular porosity in the form of periodically distributed void inclusions was also considered. Assuming collagen fibrils to be uniformly oriented in all directions led to an isotropic tissue with a Young’s modulus E= 1.90 GPa, which is of the same order of magnitude as that of woven bone in fracture calluses. By contrast, assuming fibrils to have a preferential orientation resulted in a Young’s modulus in the preferential direction of 9–16 GPa depending on the mineral content of the tissue. These results are consistent with experimental evidence for woven bone in foetuses, where collagen fibrils are aligned to a certain extent. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España |
Identificador del proyecto | DPI2014-58233-P |
Cita | García Rodríguez, J. y Martínez Reina, F.J. (2017). Elastic properties of woven bone: effect of mineral content and collagen fibrils orientation. Biomechanics and Modeling in Mechanobiology, 16 (1), 159-172. https://doi.org/10.1007/s10237-016-0808-z. |
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