dc.creator | Calero Castro, Francisco José | es |
dc.creator | Padillo Eguía, Andrés | es |
dc.creator | Durán Muñoz-Cruzado, Virginia María | es |
dc.creator | Tallón Aguilar, Luis | es |
dc.creator | Tinoco González, José | es |
dc.creator | Padillo Ruiz, Francisco Javier | es |
dc.date.accessioned | 2023-11-08T10:59:37Z | |
dc.date.available | 2023-11-08T10:59:37Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Calero Castro, F.J., Padillo Eguía, A., Durán Muñoz-Cruzado, V.M., Tallón Aguilar, L., Tinoco González, J. y Padillo Ruiz, F.J. (2023). Personalized additive manufacturing of devices for the management of enteroatmospheric fistulas. Bioengineering and Translational Medicine, e10583. https://doi.org/10.1002/btm2.10583. | |
dc.identifier.issn | 2380-6761 | es |
dc.identifier.uri | https://hdl.handle.net/11441/150299 | |
dc.description | This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium,
provided the original work is properly cited. | es |
dc.description.abstract | Additive manufacturing techniques allow the customized design of medical devices
according to the patient's requirements. Enteroatmospheric fistula is a pathology that
benefits from this personalization due to its extensive clinical variability since the size
and morphology of the wound differ extensively among patients. Standard prosthetics
do not achieve proper isolation of the wound, leading to a higher risk of infections.
Currently, no effective personalized technique to isolate it has been described.
In this work, we present the workflow for the design and manufacture of customized
devices adapted to the fistula characteristics as it evolves and changes during the
treatment with Negative Pressure Wound Therapy (NPWT). For each case, a device
was designed with dimensions and morphology depending on each patient's requirements
using white light scanning, CAD design, and additive manufacturing. The
design and manufacture of the devices were performed in 230.50 min (184.00–
304.75). After the placement of the device, the wound was successfully isolated from
the intestinal content for 48–72 h. The therapy was applied for 27.71 ± 13.74 days,
and the device was redesigned to adapt to the wound when geometrical evolutionary
changes occur during the therapy. It was observed a decrease in weekly cures from
23.63 ± 10.54 to 2.69 ± 0.65 (p = 0.001). The fistulose size was reduced longitudinal
and transversally by 3.25 ± 2.56 cm and 6.06 ± 3.14 cm, respectively. The wound
depth also decreased by 1.94 ± 1.08 cm. In conclusion, customization through
additive manufacturing is feasible and offers promising results in the generation of
personalized devices for the treatment of enteroatmospheric fistula. | es |
dc.description.sponsorship | Instituto de Salud Carlos III PI19/01821 | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | John Wiley and Sons | es |
dc.relation.ispartof | Bioengineering and Translational Medicine, e10583. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | 3D printing | es |
dc.subject | Computer-aided design | es |
dc.subject | Digestive system fistula | es |
dc.subject | Personalized medicine | es |
dc.subject | Wound care | es |
dc.subject | Wound healing | es |
dc.title | Personalized additive manufacturing of devices for the management of enteroatmospheric fistulas | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Organización Industrial y Gestión de Empresas I | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.projectID | PI19/01821 | es |
dc.relation.publisherversion | https://aiche.onlinelibrary.wiley.com/doi/10.1002/btm2.10583 | es |
dc.identifier.doi | 10.1002/btm2.10583 | es |
dc.contributor.group | Universidad de Sevilla. CTS-664: Cirugía avanzada y trasplantes. Terapia celular y bioingeniería aplicada a la cirugía. | es |
dc.journaltitle | Bioengineering and Translational Medicine | es |
dc.publication.initialPage | e10583 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |