dc.creator | Santos Carrasco, Daniel | es |
dc.creator | Casa Rivas, Luis Gonzalo de La | es |
dc.date.accessioned | 2023-08-14T10:24:48Z | |
dc.date.available | 2023-08-14T10:24:48Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Santos Carrasco, D. y Casa Rivas, L.G.d.L. (2023). Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review. BMC Psychology, 11, 226, 1-22. https://doi.org/10.1186/s40359-023-01253-9. | |
dc.identifier.issn | 2050-7283 | es |
dc.identifier.uri | https://hdl.handle.net/11441/148443 | |
dc.description.abstract | Background Psychopathological research is moving from a specific approach towards transdiagnosis through the
analysis of processes that appear transversally to multiple pathologies. A phenomenon disrupted in several disorders
is prepulse inhibition (PPI) of the startle response, in which startle to an intense sensory stimulus, or pulse, is reduced
if a weak stimulus, or prepulse, is previously presented.
Objective and methods The present systematic review analyzed the role of PPI deficit as a possible transdiagnostic
process for four main groups of neuropsychiatric disorders: (1) trauma-, stress-, and anxiety-related disorders (2)
mood-related disorders, (3) neurocognitive disorders, and (4) other disorders such as obsessive-compulsive, tic-
related, and substance use disorders. We used Web of Science, PubMed and PsycInfo databases to search for
experimental case-control articles that were analyzed both qualitatively and based on their potential risk of bias.
A total of 64 studies were included in this systematic review. Protocol was submitted prospectively to PROSPERO
04/30/2022 (CRD42022322031).
Results and conclusion The results showed a general PPI deficit in the diagnostic groups mentioned, with
associated deficits in the dopaminergic neurotransmission system, several areas implied such as the medial prefrontal
cortex or the amygdala, and related variables such as cognitive deficits and anxiety symptoms. It can be concluded
that the PPI deficit appears across most of the neuropsychiatric disorders examined, and it could be considered as a
relevant measure in translational research for the early detection of such disorders. | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación-AEI PID2019-107530GB-I00 | es |
dc.format | application/pdf | es |
dc.format.extent | 22 p. | es |
dc.language.iso | eng | es |
dc.publisher | BioMed Central | es |
dc.relation.ispartof | BMC Psychology, 11, 226, 1-22. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Sensorimotor gating | es |
dc.subject | Prepulse inhibition | es |
dc.subject | Startle response | es |
dc.subject | Neuropsychiatric disorders | es |
dc.subject | Transdiagnostic process | es |
dc.subject | Pre-attentional filtering | es |
dc.title | Prepulse inhibition deficit as a transdiagnostic process in neuropsychiatric disorders: A systematic review | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psicología Experimental | es |
dc.relation.projectID | PID2019-107530GB-I00 | es |
dc.relation.publisherversion | https://doi.org/10.1186/s40359-023-01253-9 | es |
dc.identifier.doi | 10.1186/s40359-023-01253-9 | es |
dc.journaltitle | BMC Psychology | es |
dc.publication.volumen | 11 | es |
dc.publication.initialPage | 226, 1 | es |
dc.publication.endPage | 22 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |