dc.creator | Carrasco Mantis, Ana | es |
dc.creator | Randelovic, Teodora | es |
dc.creator | Castro Abril, Héctor | es |
dc.creator | Ochoa Garrido, Ignacio | es |
dc.creator | Doblaré Castellano, Manuel | es |
dc.creator | Sanz Herrera, José Antonio | es |
dc.date.accessioned | 2023-06-26T17:19:49Z | |
dc.date.available | 2023-06-26T17:19:49Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Carrasco Mantis, A., Randelovic, T., Castro Abril, H., Ochoa Garrido, I., Doblaré Castellano, M. y Sanz Herrera, J.A. (2023). A mechanobiological model for tumor spheroid evolution with application to glioblastoma: A continuum multiphysics approach. Computers in Biology and Medicine, 159, 106897. https://doi.org/10.1016/j.compbiomed.2023.106897. | |
dc.identifier.issn | 0010-4825 | es |
dc.identifier.uri | https://hdl.handle.net/11441/147498 | |
dc.description | This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | es |
dc.description.abstract | Background: Spheroids are in vitro quasi-spherical structures of cell aggregates, eventually cultured within
a hydrogel matrix, that are used, among other applications, as a technological platform to investigate tumor
formation and evolution. Several interesting features can be replicated using this methodology, such as cell
communication mechanisms, the effect of gradients of nutrients, or the creation of realistic 3D biological
structures. The main objective of this work is to link the spheroid evolution with the mechanical activity of
cells, coupled with nutrient consumption and the subsequent cell dynamics.
Method: We propose a continuum mechanobiological model which accounts for the most relevant phenomena
that take place in tumor spheroid evolution under in vitro suspension, namely, nutrient diffusion in the
spheroid, kinetics of cellular growth and death, and mechanical interactions among the cells. The model is
qualitatively validated, after calibration of the model parameters, versus in vitro experiments of spheroids of
different glioblastoma cell lines.
Results: Our model is able to explain in a novel way quite different setups, such as spheroid growth (up to
six times the initial configuration for U-87 MG cell line) or shrinking (almost half of the initial configuration
for U-251 MG cell line); as the result of the mechanical interplay of cells driven by cellular evolution.
Conclusions: Glioblastoma tumor spheroid evolution is driven by mechanical interactions of the cell aggregate
and the dynamical evolution of the cell population. All this information can be used to further investigate
mechanistic effects in the evolution of tumors and their role in cancer disease. | es |
dc.format | application/pdf | es |
dc.format.extent | 17 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Computers in Biology and Medicine, 159, 106897. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Cellular spheroid | es |
dc.subject | Glioblastoma | es |
dc.subject | Mechanobiology | es |
dc.subject | Numerical simulation | es |
dc.subject | Finite element method | es |
dc.title | A mechanobiological model for tumor spheroid evolution with application to glioblastoma: A continuum multiphysics approach | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Mecánica de Medios Continuos y Teoría de Estructuras | es |
dc.relation.projectID | PGC2018-097257-B-C31 | es |
dc.relation.projectID | PRE2019-090391 | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0010482523003621?ref=pdf_download&fr=RR-2&rr=7dd710bc3cde218c | es |
dc.identifier.doi | 10.1016/j.compbiomed.2023.106897 | es |
dc.contributor.group | Universidad de Sevilla. TEP245: Ingeniería de las Estructuras | es |
dc.journaltitle | Computers in Biology and Medicine | es |
dc.publication.volumen | 159 | es |
dc.publication.initialPage | 106897 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Agencia Estatal de Investigación. España | es |
dc.contributor.funder | Fondo Europeo de Desarrollo Regional (FEDER) | es |
dc.contributor.funder | Gobierno de Aragón | es |
dc.contributor.funder | Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN) | es |