dc.creator | Balibrea Correa, J. | es |
dc.creator | Lerendegui Marco, Jorge | es |
dc.creator | Ladarescu, I. | es |
dc.creator | Guerrero Sánchez, Carlos | es |
dc.creator | Rodríguez González, María Teresa | es |
dc.creator | Jiménez Ramos, María del Carmen | es |
dc.creator | Fernández Martínez, B. | es |
dc.creator | Domingo Pardo, César | es |
dc.date.accessioned | 2023-05-23T18:06:48Z | |
dc.date.available | 2023-05-23T18:06:48Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Balibrea Correa, J., Lerendegui Marco, J., Ladarescu, I., Guerrero Sánchez, C., Rodríguez González, M.T., Jiménez Ramos, M.d.C.,...,Domingo Pardo, C. (2022). Hybrid in-beam PET- and Compton prompt-gamma imaging aimed at enhanced proton-range verification. European Physical Journal Plus, 137 (11). https://doi.org/10.1140/epjp/s13360-022-03414-y. | |
dc.identifier.issn | 2190-5444 | es |
dc.identifier.uri | https://hdl.handle.net/11441/146564 | |
dc.description.abstract | We report on a hybrid in-beam PET and prompt-gamma Compton imaging system aimed at quasi real-time ion-range
verification in proton-therapy treatments. Proof-of-concept experiments were carried out at the radiobiology beam line of the CNA
cyclotron facility using a set of two synchronous Compton imagers and different target materials. The time structure of the 18 MeV
proton beam was shaped with a series of beam-on and beam-off intervals, thereby mimicking a pulsed proton beam on a long time
scale. During beam-on intervals, Compton imaging was performed utilizing the high energy γ -rays promptly emitted from the nuclear
reactions occurring in the targets. In the course of the beam-off intervals in situ positron-emission tomography was accomplished
with the same imagers using the β+ decay of activated nuclei. The targets used were stacks of different materials covering also
various proton ranges and energies. A systematic study on the performance of these two complementary imaging techniques is
reported and the experimental results interpreted on the basis of Monte Carlo calculations. The results demonstrate the possibility to
combine both imaging techniques in a concomitant way, where high-efficiency prompt-gamma imaging is complemented with the
high spatial accuracy of PET. Empowered by these results we suggest that a pulsed beam with a suitable duty cycle, in conjunction
with in situ Compton- and PET-imaging may help to attain complementary information and quasi real-time range monitoring with
high accuracy. | es |
dc.description.sponsorship | European Research Council 681740 | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2019-104714GB-C21, FPA2017-83946-C2-1-P, FIS2015-71688-ERC, FPA2016-77689-C2-1-R, RTI2018-098117-B-C21, ICJ220-045122-I, FJC2020-044688-I | es |
dc.description.sponsorship | Consejo Superior de Investigaciones Científicas PIE-201750I26 | es |
dc.description.sponsorship | European Union H2020-847552 | es |
dc.description.sponsorship | Generalitat Valenciana PROMETEO/2019/007 | es |
dc.format | application/pdf | es |
dc.format.extent | 18 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | European Physical Journal Plus, 137 (11). | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Hybrid in-beam PET- and Compton prompt-gamma imaging aimed at enhanced proton-range verification | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Física Atómica, Molecular y Nuclear | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Física Aplicada II | es |
dc.relation.projectID | 681740 | es |
dc.relation.projectID | PID2019-104714GB-C21 | es |
dc.relation.projectID | FPA2017-83946-C2-1-P | es |
dc.relation.projectID | FIS2015-71688-ERC | es |
dc.relation.projectID | FPA2016-77689-C2-1-R | es |
dc.relation.projectID | RTI2018-098117-B-C21 | es |
dc.relation.projectID | ICJ220-045122-I | es |
dc.relation.projectID | FJC2020-044688-I | es |
dc.relation.projectID | PIE-201750I26 | es |
dc.relation.projectID | H2020-847552 | es |
dc.relation.projectID | PROMETEO/2019/007 | es |
dc.relation.publisherversion | https://doi.org/10.1140/epjp/s13360-022-03414-y | es |
dc.identifier.doi | 10.1140/epjp/s13360-022-03414-y | es |
dc.journaltitle | European Physical Journal Plus | es |
dc.publication.volumen | 137 | es |
dc.publication.issue | 11 | es |
dc.contributor.funder | European Research Council (ERC) | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (CSIC) | es |
dc.contributor.funder | European Union (UE). H2020 | es |
dc.contributor.funder | Generalitat Valenciana | es |