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dc.creatorCebrero Cangueiro, Taniaes
dc.creatorLabrador Herrera, Gemaes
dc.creatorCarretero-Ledesma, Martaes
dc.creatorHerrera Espejo, Sorayaes
dc.creatorÁlvarez Marín, Rocíoes
dc.creatorCisneros, José Migueles
dc.creatorPachón-Ibáñez, María Eugeniaes
dc.date.accessioned2023-05-08T13:02:44Z
dc.date.available2023-05-08T13:02:44Z
dc.date.issued2022
dc.identifier.citationCebrero Cangueiro, T., Labrador Herrera, G., Carretero-Ledesma, M., Herrera Espejo, S., Álvarez Marín, R., Cisneros, J.M. y Pachón-Ibáñez, M.E. (2022). IgM-enriched immunoglobulin improves colistin efficacy in a pneumonia model by Pseudomonas aeruginosa. LIFE SCIENCE ALLIANCE, 5 (10), e202101349. https://doi.org/10.26508/lsa.202101349.
dc.identifier.issn2575-1077es
dc.identifier.urihttps://hdl.handle.net/11441/145619
dc.description.abstractWe evaluated the efficacy of ceftazidime or colistin in combi nation with polyclonal IgM-enriched immunoglobulin (IgM-IG), in an experimental pneumonia model (C57BL/6J male mice) using two multidrug-resistant Pseudomonas aeruginosa strains, both ceftazidime-susceptible and one colistin-resistant. Pharmaco dynamically optimised antimicrobials were administered for 72 h, and intravenous IgM-IG was given as a single dose. Bacterial tissues count and the mortality were analysed. Ceftazidime was more effective than colistin for both strains. In mice infected with the colistin-susceptible strain, ceftazidime reduced the bacterial concentration in the lungs and blood (22.42 and 23.87 log10 CFU/ ml) compared with colistin (20.55 and 21.23 log10 CFU/ml, re spectively) and with the controls. Colistin plus IgM-IG reduced the bacterial lung concentrations of both colistin-susceptible and resistant strains (22.91 and 21.73 log10 CFU/g, respectively) and the bacteraemia rate of the colistin-resistant strain (244%). These results suggest that IgM-IG might be useful as an adjuvant to colistin in the treatment of pneumonia caused by multidrug resistant P. aeruginosa.es
dc.formatapplication/pdfes
dc.format.extent9 p.es
dc.language.isoenges
dc.relation.ispartofLIFE SCIENCE ALLIANCE, 5 (10), e202101349.
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPseudomonas aeruginosaes
dc.subjectImmunoglobulines
dc.subjectIgMes
dc.subjectColistines
dc.subjectPneumonia modeles
dc.titleIgM-enriched immunoglobulin improves colistin efficacy in a pneumonia model by Pseudomonas aeruginosaes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Medicinaes
dc.relation.projectIDPI-0622-2012es
dc.relation.publisherversionhttps://www.life-science-alliance.org/content/5/10/e202101349es
dc.identifier.doi10.26508/lsa.202101349es
dc.contributor.groupUniversidad de Sevilla. CTS203: Estudio Enfermedades Infecciosas.es
dc.journaltitleLIFE SCIENCE ALLIANCEes
dc.publication.volumen5es
dc.publication.issue10es
dc.publication.initialPagee202101349es
dc.contributor.funderConsejería de Salud. Junta de Andalucía.es

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Atribución 4.0 Internacional
Except where otherwise noted, this item's license is described as: Atribución 4.0 Internacional