dc.creator | Sánchez González, María del Carmen | es |
dc.creator | Hita Cantalejo, María Concepción de | es |
dc.creator | Martínez Lara, Concepción | es |
dc.creator | Sánchez González, José María | es |
dc.date.accessioned | 2023-05-05T13:54:36Z | |
dc.date.available | 2023-05-05T13:54:36Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Sánchez González, M.d.C., Hita Cantalejo, M.C.d., Martínez Lara, C. y Sánchez González, J.M. (2022). Oral isotretinoin for acne vulgaris side effects on the ocular surface: Hyaluronic acid and galacto-xyloglucan as treatment for dry eye disease signs and symptoms. Frontiers in Medicine, 9. https://doi.org/10.3389/fmed.2022.959165. | |
dc.identifier.issn | 2296-858X | es |
dc.identifier.uri | https://hdl.handle.net/11441/145500 | |
dc.description.abstract | The purpose was to assess the efficacy of 0.4% hyaluronic acid and 0.2% galacto-xyloglucan on the subjective symptoms of dry eye disease and invasive and non-invasive tear film signs in oral isotretinoin for acne vulgaris treatment. A prospective, longitudinal, single-blind, clinical study was performed in oral isotretinoin for the acne vulgaris consumer population. Subjective dry eye disease questionnaires and invasive and non-invasive tear film assessments were reported prior to and after 6 weeks of hyaluronic acid with galacto-xyloglucan (HA-GX) treatment vs. hyaluronic acid alone (HA). Participants in the HA-GX group reported a higher decrease in the ocular surface disease index (17.01 ± 11.36 score points) compared to the variation in participants in the HA group (11.61 ± 11.18 score points). Standard patient evaluation of eye dryness also decreased more in participants in the HA-GX group (4.06 ± 5.50 score points) than in participants who received HA alone (0.70 ± 3.16). Regarding non-invasive break-up time (NIBUT), participants in the HA-GX group first NIBUT achieved an increase of 1.75 ± 1.16 s while participants in the HA-alone group demonstrated an increase of only 0.54 ± 1.01 s. The HA-GX group mean NIBUT increased by of 3.72 ± 5.69 s; however, the value for the HA-alone group was 2.19 ± 5.26 s. Hyaluronic acid in combination with galacto-xyloglucan significantly decreased limbal and bulbar conjunctival redness classification and SPEED test outcomes. The inclusion of galacto-xyloglucan also increased BUT and mean NIBUT values compared to those obtained with hyaluronic acid alone. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Frontiers Media S.A. | es |
dc.relation.ispartof | Frontiers in Medicine, 9. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Acne vulgaris | es |
dc.subject | Dry eye disease | es |
dc.subject | Eyedrops | es |
dc.subject | Galacto xyloglucan | es |
dc.subject | Hyaluronic acid | es |
dc.subject | Isotretinoin | es |
dc.subject | Tear film | es |
dc.title | Oral isotretinoin for acne vulgaris side effects on the ocular surface: Hyaluronic acid and galacto-xyloglucan as treatment for dry eye disease signs and symptoms | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Física de la Materia Condensada | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Enfermería | es |
dc.relation.publisherversion | https://doi.org/10.3389/fmed.2022.959165 | es |
dc.identifier.doi | 10.3389/fmed.2022.959165 | es |
dc.journaltitle | Frontiers in Medicine | es |
dc.publication.volumen | 9 | es |