Mostrar el registro sencillo del ítem
Artículo
Mortality after transplantation for hepatocellular carcinoma: a study from the European liver transplant registry
dc.creator | Pommergaard, Hans Christian | es |
dc.creator | Rostved, Andreas Arendtsen | es |
dc.creator | Adam, René | es |
dc.creator | Salizzoni, Mauro | es |
dc.creator | Gómez Bravo, Miguel Ángel | es |
dc.creator | Cherqui, Daniel | es |
dc.creator | Thygesen, Lau Caspar | es |
dc.date.accessioned | 2023-04-25T07:27:50Z | |
dc.date.available | 2023-04-25T07:27:50Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Pommergaard, H.C., Rostved, A.A., Adam, R., Salizzoni, M., Gómez Bravo, M.Á., Cherqui, D. y Thygesen, L.C. (2020). Mortality after transplantation for hepatocellular carcinoma: a study from the European liver transplant registry. Liver Cancer, 9 (4), 455-457. https://doi.org/10.1159/000507397. | |
dc.identifier.issn | 2235-1795 | es |
dc.identifier.issn | 1664-5553 | es |
dc.identifier.uri | https://hdl.handle.net/11441/144814 | |
dc.description.abstract | Background and Aims: Prognosis after liver transplantation differs between hepatocellular carcinoma (HCC) arising in cirrhotic and non-cirrhotic livers and aetiology is poorly understood. The aim was to investigate differences in mortality after liver transplantation between these patients. Methods: We included patients from the European Liver Transplant Registry transplanted due to HCC from 1990 to November 2016 and compared cirrhotic and non-cirrhotic patients using propensity score (PS) calibration of Cox regression estimates to adjust for unmeasured confounding. Results: We included 22,787 patients, of whom 96.5% had cirrhosis. In the unadjusted analysis, non-cirrhotic patients had an increased risk of overall mortality with a hazard ratio (HR) of 1.37 (95% confidence interval [CI] 1.23–1.52). However, the HR approached unity with increasing adjustment and was 1.11 (95% CI 0.99–1.25) when adjusted for unmeasured confounding. Unadjusted, non-cirrhotic patients had an increased risk of HCC-specific mortality (HR 2.62, 95% CI 2.21–3.12). After adjustment for unmeasured confounding, the risk remained significantly increased (HR 1.62, 95% CI 1.31–2.00). Conclusions: Using PS calibration, we showed that HCC in non-cirrhotic liver has similar overall mortality, but higher HCC-specific mortality. This may be a result of a more aggressive cancer form in the non-cirrhotic liver as higher mortality could not be explained by tumour characteristics or other prognostic variables. | es |
dc.format | application/pdf | es |
dc.format.extent | 3 | es |
dc.language.iso | eng | es |
dc.publisher | S. Karger AG | es |
dc.relation.ispartof | Liver Cancer, 9 (4), 455-457. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Hepatocellular carcinoma | es |
dc.subject | Liver transplantation | es |
dc.subject | Prognosis | es |
dc.subject | Propensity score calibration | es |
dc.subject | Unmeasured confounding | es |
dc.subject | Non-cirrhotic liver · | es |
dc.subject | Cirrhosis | es |
dc.title | Mortality after transplantation for hepatocellular carcinoma: a study from the European liver transplant registry | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.publisherversion | http://doi.org/10.1159/000507397 | es |
dc.identifier.doi | 10.1159/000507397 | es |
dc.journaltitle | Liver Cancer | es |
dc.publication.volumen | 9 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 455 | es |
dc.publication.endPage | 457 | es |