dc.creator | Doyle, Stephen R. | es |
dc.creator | Søe, Martin Jensen | es |
dc.creator | Nejsum, Peter | es |
dc.creator | Betson, Martha | es |
dc.creator | Cooper, Philip J. | es |
dc.creator | Peng, Lifei | es |
dc.creator | Cutillas Barrios, Cristina | es |
dc.creator | Kapel, Christian Moliin Outzen | es |
dc.date.accessioned | 2023-04-20T10:55:00Z | |
dc.date.available | 2023-04-20T10:55:00Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Doyle, S.R., Søe, M.J., Nejsum, P., Betson, M., Cooper, P.J., Peng, L.,...,Kapel, C.M.O. (2022). Population genomics of ancient and modern Trichuris trichiura. Nature Communications, 13 (1). https://doi.org/10.1038/s41467-022-31487-x. | |
dc.identifier.issn | 2041-1723 | es |
dc.identifier.uri | https://hdl.handle.net/11441/144697 | |
dc.description.abstract | The neglected tropical disease trichuriasis is caused by the whipworm Trichuris trichiura, a
soil-transmitted helminth that has infected humans for millennia. Today, T. trichiura infects as
many as 500 million people, predominantly in communities with poor sanitary infrastructure
enabling sustained faecal-oral transmission. Using whole-genome sequencing of geographically distributed worms collected from human and other primate hosts, together with
ancient samples preserved in archaeologically-defined latrines and deposits dated up to one
thousand years old, we present the first population genomics study of T. trichiura. We
describe the continent-scale genetic structure between whipworms infecting humans and
baboons relative to those infecting other primates. Admixture and population demographic
analyses support a stepwise distribution of genetic variation that is highest in Uganda,
consistent with an African origin and subsequent translocation with human migration. Finally,
genome-wide analyses between human samples and between human and non-human primate samples reveal local regions of genetic differentiation between geographically distinct
populations. These data provide insight into zoonotic reservoirs of human-infective T. trichiura
and will support future efforts toward the implementation of genomic epidemiology of this
globally important helminth. | es |
dc.description.sponsorship | UK Research and Innovation MR/T020733/1 | es |
dc.description.sponsorship | Wellcome Trust 206194 | es |
dc.description.sponsorship | Shanxi Agricultural University 20211331-13, 2021XG001 | es |
dc.format | application/pdf | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer Nature | es |
dc.relation.ispartof | Nature Communications, 13 (1). | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Population genomics of ancient and modern Trichuris trichiura | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Microbiología y Parasitología | es |
dc.relation.projectID | MR/T020733/1 | es |
dc.relation.projectID | 206194 | es |
dc.relation.projectID | 20211331-13 | es |
dc.relation.projectID | 2021XG001 | es |
dc.relation.publisherversion | https://doi.org/10.1038/s41467-022-31487-x | es |
dc.identifier.doi | 10.1038/s41467-022-31487-x | es |
dc.journaltitle | Nature Communications | es |
dc.publication.volumen | 13 | es |
dc.publication.issue | 1 | es |
dc.contributor.funder | UK Research and Innovation (UKRI) | es |
dc.contributor.funder | Wellcome Trust | es |
dc.contributor.funder | Shanxi Agricultural University | es |