Article
Electropolymerized polypyrrole silver nanocomposite coatings on porous Ti substrates with enhanced corrosion and antibacterial behavior for biomedical applications
Author/s | García Cabezón, Cristina
Fortio Godinho, Vanda Cristina Pérez-González, C. Torres Hernández, Yadir Martín Pedrosa, Fernando |
Department | Universidad de Sevilla. Departamento de Ingeniería y Ciencia de los Materiales y del Transporte |
Publication Date | 2023-04 |
Deposit Date | 2023-04-13 |
Published in |
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Abstract | This work proposes an innovative strategy that combines two well-known easy and economical preparation techniques: powder metallurgy based space-holder (SH) technique to provide porous biocompatible Ti substrates with ... This work proposes an innovative strategy that combines two well-known easy and economical preparation techniques: powder metallurgy based space-holder (SH) technique to provide porous biocompatible Ti substrates with balanced biomechanical behavior (for cortical bone tissue substitution) promoting bone ingrowth and biocoating infiltration, and electropolymerization to coat these substrates with the polypyrrole–silver nanoparticles (PPy-AgNPs) composite conductive polymers improving its corrosion resistance, biocompatibility with enhanced antibacterial activity. The deposited PPy-based coatings present a cauliflower-like structure well adhered to the porous substrates. The macroporosity of and rough inner pore surface of Ti SH substrates are responsible for the superior adhesion of the conductive polymer comparing to typical denser substrates obtained by powder metallurgy or forging. The corrosion protection properties of the coatings were investigated by open circuit potential and Anodic Polarization in PBS media to simulate possible implant conditions, revealing improved corrosion resistance for the composite coatings. The bioactivity of the coatings was evaluated by immersion tests, revealing the formation of Hydroxyapatite after 90-day immersion in PBS. In both PPy and PPy-AgNPs composite coatings, a displacement of the polarization curves to more noble potentials and a decrease in the current density, indicated that the coating's protective character is maintained after 90-day immersion in PBS. The antibacterial activity was assessed by using the Kirby–Bauer disk-diffusion method against Staphylococcus aureus (ATCC 25923). The inhibition halo increased from 5.5 ± 0.4 mm for the bare substrate to 8.2 ± 0.6 mm for the PPy-coated substrate and to 12.5 ± 0.7 mm for the PPy-AgNPs-coated porous Ti. This feature associated to the improved corrosion protection and biocompatibility would significantly contribute to the success of the potential use of porous Ti implants by SH technique envisaging substitution of small damaged bone tissues for example in tumors. |
Funding agencies | Ministry of Science and Innovation of Spain under the grant RTI2018-097990-B-I00 Ministry of Science and Innovation of Spain under the grant PID2019-109371 GB-I00 Junta de Andalucía–FEDER (Spain) through the Project Ref. US-1259771 Junta de Castilla y León (Spain) VA275P18 Junta de Castilla y León (Spain) VA044G19 |
Project ID. | RTI2018-097990-B-I00
PID2019-109371 GB-I00 US-1259771 VA275P18 VA044G19 |
Citation | García Cabezón, C., Fortio Godinho, V.C., Pérez-González, C., Torres Hernández, Y. y Martín Pedrosa, F. (2023). Electropolymerized polypyrrole silver nanocomposite coatings on porous Ti substrates with enhanced corrosion and antibacterial behavior for biomedical applications. Materials Today Chemistry, 29 (101433). https://doi.org/10.1016/j.mtchem.2023.101433. |
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