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DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops
dc.creator | Marchena Cruz, Esther | es |
dc.creator | Camino, Lola P. | es |
dc.creator | Bhandari, Jay | es |
dc.creator | Pinela Da Silva, Sonia Cristina | es |
dc.creator | Marqueta Gracia, José Javier | es |
dc.creator | Amdeen, Shahad A. | es |
dc.creator | Guillén Mendoza, Cristina | es |
dc.creator | García Rubio, María Luisa | es |
dc.creator | Calderón Montaño, José Manuel | es |
dc.creator | Xue, Xiaoyu | es |
dc.creator | Luna Varo, Rosa María | es |
dc.creator | Aguilera López, Andrés | es |
dc.date.accessioned | 2023-03-16T17:07:09Z | |
dc.date.available | 2023-03-16T17:07:09Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Marchena Cruz, E., Camino, L.P., Bhandari, J., Pinela Da Silva, S.C., Marqueta Gracia, J.J., Amdeen, S.A.,...,Aguilera López, A. (2023). DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops. Cell Reports, 42 (3), 112148. https://doi.org/10.1016/j.celrep.2023.112148. | |
dc.identifier.issn | 2211-1247 | es |
dc.identifier.uri | https://hdl.handle.net/11441/143417 | |
dc.description.abstract | Unscheduled R loops can be a source of genome instability, a hallmark of cancer cells. Although targeted proteomic approaches and cellular analysis of specific mutants have uncovered factors potentially involved in R-loop homeostasis, we report a more open screening of factors whose depletion causes R loops based on the ability of activation-induced cytidine deaminase (AID) to target R loops. Immunofluorescence analysis of gH2AX caused by small interfering RNAs (siRNAs) covering 3,205 protein-coding genes identifies 59 potential candidates, from which 13 are analyzed further and show a significant increase of R loops. Such candidates are enriched in factors involved in chromatin, transcription, and RNA biogenesis and other processes. A more focused study shows that the DDX47 helicase is an R-loop resolvase, whereas the MeCP2 methyl-CpG-binding protein uncovers a link between DNA methylation and R loops. Thus, our results suggest that a plethora of gene dysfunctions can alter cell physiology via affecting R-loop homeostasis by different mechanisms. | es |
dc.description.sponsorship | Ministerio de Ciecia e Innovación PID2019-104270GB-I00/BMC | es |
dc.description.sponsorship | European Research Council ERC2014 AdG669898 TARLOOP | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad BFU2016-75058-P | es |
dc.description.sponsorship | National Institutes of Health R15 GM139135, R21 ES028792 | es |
dc.format | application/pdf | es |
dc.format.extent | 23 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Cell Reports, 42 (3), 112148. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | DDX47, MeCP2, and other functionally heterogeneous factors protect cells from harmful R loops | es |
dc.type | info:eu-repo/semantics/article | es |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Genética | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología | es |
dc.relation.projectID | PID2019-104270GB-I00/BMC | es |
dc.relation.projectID | ERC2014 AdG669898 TARLOOP | es |
dc.relation.projectID | BFU2016-75058-P | es |
dc.relation.projectID | R15 GM139135 | es |
dc.relation.projectID | R21 ES028792 | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.celrep.2023.112148 | es |
dc.identifier.doi | 10.1016/j.celrep.2023.112148 | es |
dc.journaltitle | Cell Reports | es |
dc.publication.volumen | 42 | es |
dc.publication.issue | 3 | es |
dc.publication.initialPage | 112148 | es |
dc.contributor.funder | Ministerio de Ciencia e Innovación (MICIN). España | es |
dc.contributor.funder | European Research Council (ERC) | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |
dc.description.awardwinning | Premio Mensual Publicación Científica Destacada de la US. Facultad de Biología |