dc.creator | Esteban Ortega, Francisco | es |
dc.creator | Ramos García, Pablo | es |
dc.creator | Muñoz, Miguel | es |
dc.creator | González Moles, Miguel Ángel | es |
dc.date.accessioned | 2022-11-30T14:41:57Z | |
dc.date.available | 2022-11-30T14:41:57Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Esteban Ortega, F., Ramos García, P., Muñoz, M. y González Moles, M.Á. (2022). Substance P and Neurokinin 1 Receptor in Chronic Inflammation and Cancer of the Head and Neck: A Review of the Literature. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19 (1), 375. https://doi.org/10.3390/ijerph19010375. | |
dc.identifier.issn | 1660-4601 | es |
dc.identifier.issn | 1661-7827 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139942 | |
dc.description.abstract | Head and neck cancer is a growing worldwide public health problem, accounting for
approximately 1,500,000 new cases and 500,000 deaths annually. Substance P (SP) is a peptide of
the tachykinin family, which has roles related to a large number of physiological mechanisms in
humans. The implications of SP in carcinogenesis have recently been reported through the stimulation
of the neurokinin 1 receptor (NK1R), or directly, through the effects derived from the constitutive
activation of NK1R. Consequently, SP/NK1R seems to play relevant roles in cancer, upregulating cell
proliferation, cell migration and chronic inflammation, among other oncogenic actions. Furthermore,
there is growing evidence pointing to a central role for SP in tumour progression, singularly so in
laryngeal and oral squamous cell carcinomas. The current narrative review of the literature focuses
on the relationship between the SP/NK1R system and chronic inflammation and cancer in the head and-neck region. We described a role for SP/NK1R in the transition from chronic inflammation of the
head and neck mucosa, to preneoplastic and neoplastic transformation and progression. | es |
dc.format | application/pdf | es |
dc.format.extent | 15 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 19 (1), 375. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Substance P | es |
dc.subject | NK1R | es |
dc.subject | Head and neck cancer | es |
dc.subject | Squamous cell carcinoma | es |
dc.subject | Chronic inflammation | es |
dc.title | Substance P and Neurokinin 1 Receptor in Chronic Inflammation and Cancer of the Head and Neck: A Review of the Literature | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.publisherversion | https://www.mdpi.com/1660-4601/19/1/375 | es |
dc.identifier.doi | 10.3390/ijerph19010375 | es |
dc.contributor.group | Universidad de Sevilla. CTS392: Biopatología del carcinoma escamoso de cabeza y cuello. | es |
dc.journaltitle | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | es |
dc.publication.volumen | 19 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 375 | es |