dc.creator | Palomo-López, Nora | es |
dc.creator | Rodríguez Rodríguez, Ana | es |
dc.creator | Martín Villén, Luis Guillermo | es |
dc.creator | Mendoza Prieto, María | es |
dc.creator | Ruiz de Azúa López, Zaida | es |
dc.creator | Sempere Bordes, Lluis | es |
dc.creator | Vilches Arenas, Ángel | es |
dc.creator | Egea Guerrero, Juan José | es |
dc.date.accessioned | 2022-11-25T16:32:16Z | |
dc.date.available | 2022-11-25T16:32:16Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Palomo-López, N., Rodríguez Rodríguez, A., Martín Villén, L.G., Mendoza Prieto, M., Ruiz de Azúa López, Z., Sempere Bordes, L.,...,Antioxidant effect, (2022). Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results. Healthcare, 10 (5), 762. https://doi.org/10.3390/healthcare10050762. | |
dc.identifier.issn | 2227-9032 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139815 | |
dc.description.abstract | The objective was to quantify oxidative stress resulting from ischemia during the donation
process, using malondialdehyde (MDA) measurement, and its modulation by the administration of
melatonin. We designed a triple-blind clinical trial with donors randomized to melatonin or placebo.
We collected donors by donation after brain death (DBD) and controlled donation after circulatory
death (DCD), the latter maintained by normothermic regional perfusion (NRP). Melatonin or placebo
was administered prior to donation or following limitation of therapeutic effort (LTE). Demographic
variables and medical history were collected. We also collected serial measurements of MDA, at
60 and 90 min after melatonin or placebo administration. A total of 53 donors were included (32 from
DBD and 21 from DCD). In the DBD group, 17 donors received melatonin, and 15 placebo. Eight
DCD donors were randomized to melatonin and 13 to placebo. Medical history and cause for LTE
were similar between groups. Although MDA values did not differ in the DBD group, statistical
differences were observed in DCD donors during the 0–60 min interval: −4.296 (−6.752; −2.336)
in the melatonin group and −1.612 (−2.886; −0.7445) in controls. Given the antioxidant effect of
melatonin, its use could reduce the production of oxidative stress in controlled DCD. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Healthcare, 10 (5), 762. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Brain death donor | es |
dc.subject | Donation after circulatory death | es |
dc.subject | Ischemia | es |
dc.subject | Oxidative stress | es |
dc.subject | Malondialdehyde | es |
dc.subject | Melatonin | es |
dc.subject | Antioxidant effect | es |
dc.title | Immunomodulation of Oxidative Stress during Organ Donation Process: Preliminary Results | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina Preventiva y Salud Pública | es |
dc.relation.publisherversion | https://www.mdpi.com/2227-9032/10/5/762 | es |
dc.identifier.doi | 10.3390/healthcare10050762 | es |
dc.contributor.group | Universidad de Sevilla. CTS312: Análisis de la demanda sanitaria. | es |
dc.journaltitle | Healthcare | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 762 | es |