Artículo
SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome
Autor/es | Salto Alejandre, Sonsoles
Berastegui-Cabrera, Judith Camacho-Martínez, Pedro Infante-Domínguez, Carmen Carretero-Ledesma, Marta Crespo-Rivas, Juan Carlos Lepe Jiménez, José Antonio Cisneros, José Miguel Pachón Díaz, Jerónimo Cordero Matia, María Elisa Sánchez-Céspedes, Javier Barón-Franco, Bosco Bernabeu Wittel, Máximo López Cortés, Luis Fernando Nieto Martín, María Dolores Romero Rodríguez, María de las Nieves Ampuero Herrojo, Javier |
Departamento | Universidad de Sevilla. Departamento de Microbiología Universidad de Sevilla. Departamento de Medicina |
Fecha de publicación | 2021 |
Fecha de depósito | 2022-11-14 |
Publicado en |
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Resumen | The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at frst patient’s hospital
evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321
adult patients with ... The aim was to assess the ability of nasopharyngeal SARS-CoV-2 viral load at frst patient’s hospital evaluation to predict unfavorable outcomes. We conducted a prospective cohort study including 321 adult patients with confrmed COVID-19 through RT-PCR in nasopharyngeal swabs. Quantitative Synthetic SARS-CoV-2 RNA cycle threshold values were used to calculate the viral load in log10 copies/mL. Disease severity at the end of follow up was categorized into mild, moderate, and severe. Primary endpoint was a composite of intensive care unit (ICU) admission and/or death (n= 85, 26.4%). Univariable and multivariable logistic regression analyses were performed. Nasopharyngeal SARS-CoV-2 viral load over the second quartile (≥7.35 log10 copies/mL, p = 0.003) and second tertile (≥ 8.27 log10 copies/mL, p = 0.01) were associated to unfavorable outcome in the unadjusted logistic regression analysis. However, in the fnal multivariable analysis, viral load was not independently associated with an unfavorable outcome. Five predictors were independently associated with increased odds of ICU admission and/or death: age≥ 70 years, SpO2, neutrophils > 7.5 × 103 /µL, lactate dehydrogenase≥ 300 U/L, and C-reactive protein≥ 100 mg/L. In summary, nasopharyngeal SARS-CoV-2 viral load on admission is generally high in patients with COVID-19, regardless of illness severity, but it cannot be used as an independent predictor of unfavorable clinical outcome. |
Agencias financiadoras | National Plan R+D+I 2013–2016 Instituto de Salud Carlos III Ministerio de Economía, Industria y Competitividad. España Servicio Andaluz de Salud, Junta de Andalucía, España. |
Identificador del proyecto | REIPI RD16/0016/0009
COV20/00370 COV20/00580 C-0059-2018 |
Cita | Salto-Alejandre, S., Berastegui-Cabrera, J., Camacho-Martínez, P., Infante-Domínguez, C., Carretero-Ledesma, M., Crespo-Rivas, J.C.,...,Ampuero Herrojo, J. (2021). SARS-CoV-2 viral load in nasopharyngeal swabs is not an independent predictor of unfavorable outcome. Scientific Reports, 11 (1), 12931. https://doi.org/10.1038/s41598-021-92400-y. |
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