dc.creator | Rodríguez Gil, Alfonso | es |
dc.creator | Carrillo-Cruz, Estrella | es |
dc.creator | Marrero-Cepeda, Cristina | es |
dc.creator | Rodríguez, Guillermo | es |
dc.creator | Pérez Simón, José Antonio | es |
dc.date.accessioned | 2022-11-14T13:58:15Z | |
dc.date.available | 2022-11-14T13:58:15Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Rodríguez Gil, A., Carrillo-Cruz, E., Marrero-Cepeda, C., Rodríguez, G. y Pérez Simón, J.A. (2022). Effect of Vitamin D on Graft-versus-Host Disease. Biomedicines, 10 (5), 987. https://doi.org/10.3390/biomedicines10050987. | |
dc.identifier.issn | 2227-9059 | es |
dc.identifier.uri | https://hdl.handle.net/11441/139395 | |
dc.description.abstract | The different cell subsets of the immune system express the vitamin D receptor (VDR).
Through the VDR, vitamin D exerts different functions that influence immune responses, as previously
shown in different preclinical models. Based on this background, retrospective studies explored the
impacts of vitamin D levels on the outcomes of patients undergoing allogeneic hematopoietic stem cell transplantation, showing that vitamin D deficiency is related to an increased risk of complications,
especially graft-versus-host disease. These results were confirmed in a prospective cohort trial,
although further studies are required to confirm this data. In addition, the role of vitamin D on the
treatment of hematologic malignancies was also explored. Considering this dual effect on both the
immune systems and tumor cells of patients with hematologic malignancies, vitamin D might be
useful in this setting to decrease both graft-versus-host disease and relapse rates. | es |
dc.format | application/pdf | es |
dc.format.extent | 26 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI | es |
dc.relation.ispartof | Biomedicines, 10 (5), 987. | |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Vitamin D | es |
dc.subject | Calcifediol | es |
dc.subject | Calcitriol | es |
dc.subject | Graft-versus-host disease | es |
dc.subject | Vitamin D receptor (VDR) | es |
dc.title | Effect of Vitamin D on Graft-versus-Host Disease | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Fisiología Médica y Biofísica | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.publisherversion | https://www.mdpi.com/2227-9059/10/5/987 | es |
dc.identifier.doi | 10.3390/biomedicines10050987 | es |
dc.journaltitle | Biomedicines | es |
dc.publication.volumen | 10 | es |
dc.publication.issue | 5 | es |
dc.publication.initialPage | 987 | es |