dc.creator | Martínez-Pérez, Óscar | es |
dc.creator | Prats Rodríguez, Pilar | es |
dc.creator | Muner Hernández, Marta | es |
dc.creator | Encinas Pardilla, María Begoña | es |
dc.creator | Pérez Pérez, Noelia | es |
dc.creator | Vila Hernández, María Rosa | es |
dc.creator | Guadix, Pilar | es |
dc.creator | Sáinz Bueno, José Antonio | es |
dc.date.accessioned | 2022-11-02T16:04:35Z | |
dc.date.available | 2022-11-02T16:04:35Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Martínez-Pérez, Ó., Prats Rodríguez, P., Muner Hernández, M., Encinas Pardilla, M.B., Pérez Pérez, N., Vila Hernández, M.R.,...,Sáinz Bueno, J.A. (2021). The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis. BMC Pregnancy and Childbirth, 21 (1), 273. https://doi.org/10.1186/s12884-021-03742-4. | |
dc.identifier.issn | 1471-2393 | es |
dc.identifier.uri | https://hdl.handle.net/11441/138609 | |
dc.description.abstract | Background: To determine whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the cause of
COVID-19 disease) exposure in pregnancy, compared to non-exposure, is associated with infection-related obstetric
morbidity.
Methods: We conducted a multicentre prospective study in pregnancy based on a universal antenatal screening
program for SARS-CoV-2 infection. Throughout Spain 45 hospitals tested all women at admission on delivery ward
using polymerase-chain-reaction (PCR) for COVID-19 since late March 2020. The cohort of positive mothers and the
concurrent sample of negative mothers was followed up until 6-weeks post-partum. Multivariable logistic regression
analysis, adjusting for known confounding variables, determined the adjusted odds ratio (aOR) with 95% confidence
intervals (95% CI) of the association of SARS-CoV-2 infection and obstetric outcomes. Main outcome measures:
Preterm delivery (primary), premature rupture of membranes and neonatal intensive care unit admissions.
Results: Among 1009 screened pregnancies, 246 were SARS-CoV-2 positive. Compared to negative mothers (763
cases), SARS-CoV-2 infection increased the odds of preterm birth (34 vs 51, 13.8% vs 6.7%, aOR 2.12, 95% CI 1.32–
3.36, p = 0.002); iatrogenic preterm delivery was more frequent in infected women (4.9% vs 1.3%, p = 0.001), while
the occurrence of spontaneous preterm deliveries was statistically similar (6.1% vs 4.7%). An increased risk of
premature rupture of membranes at term (39 vs 75, 15.8% vs 9.8%, aOR 1.70, 95% CI 1.11–2.57, p = 0.013) and
neonatal intensive care unit admissions (23 vs 18, 9.3% vs 2.4%, aOR 4.62, 95% CI 2.43–8.94, p < 0.001) was also
observed in positive mothers.
Conclusion: This prospective multicentre study demonstrated that pregnant women infected with SARS-CoV-2
have more infection-related obstetric morbidity. This hypothesis merits evaluation of a causal association in further
research. | es |
dc.format | application/pdf | es |
dc.format.extent | 11 p. | es |
dc.language.iso | eng | es |
dc.publisher | BIOMED CENTRAL LTD | es |
dc.relation.ispartof | BMC Pregnancy and Childbirth, 21 (1), 273. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | SARS-CoV-2 | es |
dc.subject | Coronavirus | es |
dc.subject | COVID-19 | es |
dc.subject | Pregnancy | es |
dc.subject | Premature birth | es |
dc.subject | Premature rupture of membranes | es |
dc.subject | Intensive care units | es |
dc.subject | Neonatal | es |
dc.title | The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.projectID | COV20/00021 | es |
dc.relation.publisherversion | https://bmcpregnancychildbirth.biomedcentral.com/articles/10.1186/s12884-021-03742-4 | es |
dc.identifier.doi | 10.1186/s12884-021-03742-4 | es |
dc.journaltitle | BMC Pregnancy and Childbirth | es |
dc.publication.volumen | 21 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 273 | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |