dc.creator | Berkell, Matilda | es |
dc.creator | Mysara, Mohamed | es |
dc.creator | Xavier, Basil Britto | es |
dc.creator | van Werkhoven, Cornelis H. | es |
dc.creator | Monsieurs, Pieter | es |
dc.creator | Lammens, Christine | es |
dc.creator | Rodríguez-Baño, Jesús | es |
dc.date.accessioned | 2022-10-26T13:47:47Z | |
dc.date.available | 2022-10-26T13:47:47Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Berkell, M., Mysara, M., Xavier, B.B., van Werkhoven, C.H., Monsieurs, P., Lammens, C. y Rodríguez-Baño, J. (2021). Microbiota-based markers predictive of development of Clostridioides difficile infection. Nature Communications, 12 (1), 2241. https://doi.org/10.1038/s41467-021-22302-0. | |
dc.identifier.issn | 2041-1723 | es |
dc.identifier.uri | https://hdl.handle.net/11441/138381 | |
dc.description.abstract | Antibiotic-induced modulation of the intestinal microbiota can lead to Clostridioides difficile
infection (CDI), which is associated with considerable morbidity, mortality, and healthcare costs globally. Therefore, identification of markers predictive of CDI could substantially
contribute to guiding therapy and decreasing the infection burden. Here, we analyze the
intestinal microbiota of hospitalized patients at increased CDI risk in a prospective, 90-day
cohort-study before and after antibiotic treatment and at diarrhea onset. We show that
patients developing CDI already exhibit significantly lower diversity before antibiotic treat ment and a distinct microbiota enriched in Enterococcus and depleted of Ruminococcus, Blautia,
Prevotella and Bifidobacterium compared to non-CDI patients. We find that antibiotic
treatment-induced dysbiosis is class-specific with beta-lactams further increasing enter ococcal abundance. Our findings, validated in an independent prospective patient cohort
developing CDI, can be exploited to enrich for high-risk patients in prospective clinical trials,
and to develop predictive microbiota-based diagnostics for management of patients at
risk for CDI. | es |
dc.format | application/pdf | es |
dc.format.extent | 14 p. | es |
dc.language.iso | eng | es |
dc.publisher | Nature Publishing Group | es |
dc.relation.ispartof | Nature Communications, 12 (1), 2241. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Clostridioides difficile | es |
dc.title | Microbiota-based markers predictive of development of Clostridioides difficile infection | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Medicina | es |
dc.relation.projectID | 675412 | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41467-021-22302-0 | es |
dc.identifier.doi | 10.1038/s41467-021-22302-0 | es |
dc.contributor.group | Universidad de Sevilla. CTS 406: Estudio Enfermedades Infecciosas en la Práctica Clínica. | es |
dc.journaltitle | Nature Communications | es |
dc.publication.volumen | 12 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 2241 | es |
dc.contributor.funder | Unión Europea | es |