dc.creator | Kurch, Lars | es |
dc.creator | Mauz-Körholz, Christine | es |
dc.creator | Fosså, Alexander | es |
dc.creator | Georgi, Thomas Walther | es |
dc.creator | Kluge, Regine | es |
dc.creator | Bartelt, Jörg Martin | es |
dc.creator | Fernández-Teijeiro, Ana | es |
dc.creator | Stoevesandt, Dietrich | es |
dc.date.accessioned | 2022-09-27T15:39:15Z | |
dc.date.available | 2022-09-27T15:39:15Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Kurch, L., Mauz-Körholz, C., Fosså, A., Georgi, T.W., Kluge, R., Bartelt, J.M.,...,Stoevesandt, D. (2021). Assessment of Waldeyer’s ring in pediatric and adolescent Hodgkin lymphoma patients—Importance ofmultimodality imaging: Results from the EuroNet-PHL-C1 trial. Pediatric Blood & Cancer, 68 (4) | |
dc.identifier.issn | 1545-5009 | es |
dc.identifier.issn | 1545-5017 (electrónico) | es |
dc.identifier.uri | https://hdl.handle.net/11441/137408 | |
dc.description.abstract | Background: In the EuroNet Pediatric Hodgkin Lymphoma (EuroNet-PHL) trials, decision
onWaldeyer’s ring (WR) involvement is usually based on clinical assessment, that
is, physical examination and/or nasopharyngoscopy. However, clinical assessment only
evaluates mucosal surface and is prone to interobserver variability. Modern crosssectional
imaging technology may provide valuable information beyond mucosal surface,
which may lead to a more accurateWRstaging.
Patients,materials, and methods: The EuroNet-PHL-C1 trial recruited 2102 patients,
of which 1752 underwent central review including reference reading of their crosssectional
imaging data. In 14 of 1752 patients, WR was considered involved according
to clinical assessment. In these 14 patients, the WR was re-assessed by applying
an imaging-based algorithm considering information from 18F-fluorodeoxyglucose
positron emission tomography, contrast-enhanced computed tomography, and/or magnetic
resonance imaging. For verification purposes, the imaging-based algorithm was
applied to 100 consecutive patients whose WR was inconspicuous on clinical assessment.
Results: The imaging-based algorithm confirmedWRinvolvement only in four of the 14
patients. Of the remaining 10 patients, four had retropharyngeal lymph node involvement
and six an inconspicuous WR. Applying the imaging-based algorithm to 100 consecutive
patients with physiological appearance of their WR on clinical assessment,
absence of WR involvement could be confirmed in 99. However, suspicion of WR
involvement was raised in one patient.
Conclusions: The imaging-based algorithm was feasible and easily applicable at initial
staging of young patients with Hodgkin lymphoma. It increased the accuracy of WR
staging, which may contribute to a more individualized treatment in the future. | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | WILEY-BLACKWELL | es |
dc.relation.ispartof | Pediatric Blood & Cancer, 68 (4) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | F-FDG-PET | es |
dc.subject | ENT investigation | es |
dc.subject | MRI | es |
dc.subject | Multimodality imaging | es |
dc.subject | CT | es |
dc.subject | Pediatric Hodgkin lymphoma | es |
dc.subject | Staging | es |
dc.subject | Waldeyer’s ring | es |
dc.title | Assessment of Waldeyer’s ring in pediatric and adolescent Hodgkin lymphoma patients—Importance ofmultimodality imaging: Results from the EuroNet-PHL-C1 trial | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacología, Pediatría y Radiología | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/epdf/10.1002/pbc.28903 | es |
dc.identifier.doi | 10.1002/pbc.28903 | es |
dc.journaltitle | Pediatric Blood & Cancer | es |
dc.publication.volumen | 68 | es |
dc.publication.issue | 4 | es |