dc.creator | Blanco Fernández, Gerardo | es |
dc.creator | Fondevila Campo, Constantino | es |
dc.creator | Sanjuanbenito, Alfonso | es |
dc.creator | Rodríguez López, Mario | es |
dc.creator | Pérez Alonso, Alejandro J. | es |
dc.creator | Gómez Bravo, Miguel Ángel | es |
dc.creator | Rojas Holguín, Adela | es |
dc.date.accessioned | 2022-09-14T16:02:13Z | |
dc.date.available | 2022-09-14T16:02:13Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Blanco Fernández, ., Fondevila Campo, ., Sanjuanbenito, A., Rodríguez López, M., Pérez Alonso, A.J., Gómez Bravo, M.Á. y Rojas Holguín, A. (2022). Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID). EJSO, 48 (1), 133-141. | |
dc.identifier.issn | 0748-7983 | es |
dc.identifier.issn | 1532-2157 | es |
dc.identifier.uri | https://hdl.handle.net/11441/137068 | |
dc.description.abstract | Background: Renal Cell Carcinoma (RCC) occasionally spreads to the pancreas. The purpose of our study
is to evaluate the short and long-term results of a multicenter series in order to determine the effect of
surgical treatment on the prognosis of these patients.
Methods: Multicenter retrospective study of patients undergoing surgery for RCC pancreatic metastases,
from January 2010 to May 2020. Variables related to the primary tumor, demographics, clinical char-
acteristics of metastasis, location in the pancreas, type of pancreatic resection performed and data on
short and long-term evolution after pancreatic resection were collected.
Results: The study included 116 patients. The mean time between nephrectomy and pancreatic metas-
tases’ resection was 87.35 months (ICR: 1.51e332.55). Distal pancreatectomy was the most performed
technique employed (50 %). Postoperative morbidity was observed in 60.9 % of cases (Clavien-Dindo
greater than IIIa in 14 %). The median follow-up time was 43 months (13e78). Overall survival (OS) rates
at 1, 3, and 5 years were 96 %, 88 %, and 83 %, respectively. The disease-free survival (DFS) rate at 1, 3, and
5 years was 73 %, 49 %, and 35 %, respectively. Significant prognostic factors of relapse were a disease free
interval of less than 10 years (2.05 [1.13e3.72], p 0.02) and a history of previous extrapancreatic
metastasis (2.44 [1.22e4.86], p 0.01).
Conclusions: Pancreatic resection if metastatic RCC is found in the pancreas is warranted to achieve
higher overall survival and disease-free survival, even if extrapancreatic metastases were previously
removed. The existence of intrapancreatic multifocal compromise does not always warrant the perfor-
mance of a total pancreatectomy in order to improve survival. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | ELSEVIER SCI LTD | es |
dc.relation.ispartof | EJSO, 48 (1), 133-141. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Renal cell carcinoma | es |
dc.subject | Pancreatectomy | es |
dc.subject | Metastases | es |
dc.subject | Recurrence | es |
dc.title | Pancreatic metastases from renal cell carcinoma. Postoperative outcome after surgical treatment in a Spanish multicenter study (PANMEKID) | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0748798321006818?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.ejso.2021.08.011 | es |
dc.journaltitle | EJSO | es |
dc.publication.volumen | 48 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | 133 | es |
dc.publication.endPage | 141 | es |