dc.creator | Simón Soro, Áurea | es |
dc.creator | Kim, Dongyeop | es |
dc.creator | Li, Yong | es |
dc.creator | Liu, Yuan | es |
dc.creator | Ito, Tatsuro | es |
dc.creator | Sims, Kenneth R. | es |
dc.creator | Koo, Hyun | es |
dc.date.accessioned | 2022-09-12T15:07:57Z | |
dc.date.available | 2022-09-12T15:07:57Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Simón Soro, Á., Kim, D., Li, Y., Liu, Y., Ito, T., Sims, K.R. y Koo, H. (2021). Impact of the repurposed drug thonzonium bromide on host oral-gut microbiomes. npj Biofilms and Microbiomes, 7 (1) | |
dc.identifier.issn | 2055-5008 | es |
dc.identifier.uri | https://hdl.handle.net/11441/136988 | |
dc.description.abstract | Drug repurposing is a feasible strategy for the development of novel therapeutic applications. However, its potential use for oral
treatments and impact on host microbiota remain underexplored. Here, we assessed the influences of topical oral applications of a
repurposed FDA-approved drug, thonzonium bromide, on gastrointestinal microbiomes and host tissues in a rat model of dental
caries designed to reduce cross-contamination associated with coprophagy. Using this model, we recapitulated the body site
microbiota that mirrored the human microbiome profile. Oral microbiota was perturbed by the treatments with specific disruption
of Rothia and Veillonella without affecting the global composition of the fecal microbiome. However, disturbances in the oral-gut
microbial interactions were identified using nestedness and machine learning, showing increased sharing of oral taxon Sutterella in
the gut microbiota. Host-tissue analyses revealed caries reduction on teeth by thonzonium bromide without cytotoxic effects,
indicating bioactivity and biocompatibility when used orally. Altogether, we demonstrate how an oral treatment using a
repurposed drug causes localized microbial disturbances and therapeutic effects while promoting turnover of specific oral species
in the lower gut in vivo. | es |
dc.format | application/pdf | es |
dc.format.extent | 9 p. | es |
dc.language.iso | eng | es |
dc.publisher | Springer Science and Business Media LLC | es |
dc.relation.ispartof | npj Biofilms and Microbiomes, 7 (1) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Microbiomes | es |
dc.title | Impact of the repurposed drug thonzonium bromide on host oral-gut microbiomes | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Estomatología | es |
dc.relation.publisherversion | https://www.nature.com/articles/s41522-020-00181-5 | es |
dc.identifier.doi | 10.1038/s41522-020-00181-5 | es |
dc.journaltitle | npj Biofilms and Microbiomes | es |
dc.publication.volumen | 7 | es |
dc.publication.issue | 1 | es |