dc.creator | Montes Carmona, José Francisco | es |
dc.creator | González Pérez, Luis Miguel | es |
dc.creator | Infante Cossío, Pedro Antonio | es |
dc.date.accessioned | 2022-09-02T15:12:48Z | |
dc.date.available | 2022-09-02T15:12:48Z | |
dc.date.issued | 2020-12-23 | |
dc.identifier.citation | Montes Carmona, J.F., González Pérez, L.M. y Infante Cossío, P.A. (2020). Treatment of Localized and Referred Masticatory Myofascial Pain with Botulinum Toxin Injection. Toxins, 13 (6) | |
dc.identifier.issn | 2072-6651 | es |
dc.identifier.uri | https://hdl.handle.net/11441/136652 | |
dc.description.abstract | Botulinum toxin type A (BTA) injection is considered an available alternative treatment for
myofascial pain. However, its efficacy in treating masticatory myofascial pain syndrome (MMPS)
remains unclear. The purpose of this study was to evaluate whether the BTA injection into the affected
muscles would significantly reduce pain and improve function, and to assess its efficacy, safety,
and therapeutic indications in a randomized, single-center clinical trial. Sixty patients with MMPS
were randomized into three groups evenly to receive a single session injection of saline solution
(SS group), lidocaine (LD group), and BTA (BTA group) in the masseter, temporal, and pterygoid muscles
after an electromyographic study. Patients’ pain was classified as localized or referred according
to the DC/TMD classification. Assessments were performed on pre-treatment, and subsequently,
on days 7, 14, 28, 60, 90, and 180. A significant reduction in pain and improvement of mandibular
movements was found in the BTA group compared to the SS and LD groups. The response lasted
until day 180 and was more intense in patients with localized myalgia and focused myofascial pain
than in referred remote pain. No significant adverse reactions were observed. A single BTA injection
can be considered an effective treatment option in patients with localized MMPS by reducing pain
and improving mandibular movements, which persisted up to 6 months. | es |
dc.description.sponsorship | European Development Regional Fund | es |
dc.description.sponsorship | Carlos III Healthcare Institute-Health Research Fund | es |
dc.format | application/pdf | es |
dc.format.extent | 13 p. | es |
dc.language.iso | eng | es |
dc.publisher | MDPI AG | es |
dc.relation.ispartof | Toxins, 13 (6) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Temporomandibular disorders | es |
dc.subject | Masticatory myofascial pain syndrome | es |
dc.subject | Botulinum toxin | es |
dc.subject | Randomized controlled trial | es |
dc.title | Treatment of Localized and Referred Masticatory Myofascial Pain with Botulinum Toxin Injection | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Cirugía | es |
dc.relation.projectID | PI16/00970 | es |
dc.relation.publisherversion | https://www.mdpi.com/2072-6651/13/1/6/htm | es |
dc.identifier.doi | 10.3390/toxins13010006 | es |
dc.journaltitle | Toxins | es |
dc.publication.volumen | 13 | es |
dc.publication.issue | 6 | es |