dc.creator | Navarro Pando, José Manuel | es |
dc.creator | Alcocer-Gómez, Elísabet | es |
dc.creator | Castejón Vega, Beatriz | es |
dc.creator | Navarro Villarán, Elena | es |
dc.creator | Condés Hervás, Mónica | es |
dc.creator | Mundi Roldán, María | es |
dc.creator | Muntané Relat, Jordi | es |
dc.creator | Pérez Pulido, Antonio J. | es |
dc.creator | Bullon, Pedro | es |
dc.creator | Wang, Chun | es |
dc.creator | Hoffman, Hal M. | es |
dc.creator | Sanz Montero, Alberto | es |
dc.creator | Mbalaviele, Gabriel | es |
dc.creator | Ryffel, Bernhard | es |
dc.creator | Cordero, Mario D. | es |
dc.date.accessioned | 2022-08-25T08:49:39Z | |
dc.date.available | 2022-08-25T08:49:39Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Navarro Pando, J.M., Alcocer Gómez, E.I., Castejón Vega, B., Navarro Villarán, E., Condés Hervás, M., Mundi Roldán, M.,...,Cordero, M.D. (2021). Inhibition of the NLRP3 inflammasome prevents ovarian aging. Science Advances, 7 (1), Article 7409. | |
dc.identifier.issn | 2375-2548 | es |
dc.identifier.uri | https://hdl.handle.net/11441/136435 | |
dc.description.abstract | Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in female mice to levels comparable to those of Nlrp3−/− mice. These results suggest that the NLRP3 inflammasome is implicated in the age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility | es |
dc.format.extent | 12 p. | es |
dc.language.iso | eng | es |
dc.publisher | American Association for the Advancement of Science | es |
dc.relation.ispartof | Science Advances, 7 (1), Article 7409. | |
dc.rights | Attribution-NonCommercial 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.title | Inhibition of the NLRP3 inflammasome prevents ovarian aging | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Psicología Experimental | es |
dc.relation.publisherversion | https://dx.doi.org/10.1126/sciadv.abc7409 | es |
dc.identifier.doi | 10.1126/sciadv.abc7409 | es |
dc.journaltitle | Science Advances | es |
dc.publication.volumen | 7 | es |
dc.publication.issue | 1 | es |
dc.publication.initialPage | Article 7409 | es |