dc.creator | Gómez Pinto, Irene | es |
dc.creator | Vengut Climent, Empar | es |
dc.creator | Lucas Rodríguez, Ricardo | es |
dc.creator | Aviñó, Anna | es |
dc.creator | Eritja, Ramón | es |
dc.creator | González, Carlos | es |
dc.creator | Morales, Juan Carlos | es |
dc.date.accessioned | 2022-07-12T15:56:00Z | |
dc.date.available | 2022-07-12T15:56:00Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Gómez Pinto, I., Vengut Climent, E., Lucas Rodríguez, R., Aviñó, A., Eritja, R., González, C. y Morales, J.C. (2013). Carbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-End. Chemistry - A European Journal, 19 (6), 1920-1927. | |
dc.identifier.issn | 0947-6539 | es |
dc.identifier.issn | 1521-3765 | es |
dc.identifier.uri | https://hdl.handle.net/11441/135278 | |
dc.description.abstract | Quadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, supramolecular chemistry to nanoscience. We have prepared carbohydrate-DNA conjugates containing the oligonucleotide sequences of G-quadruplexes (thrombin binding aptamer (TBA) and human telomere (TEL)), measured their thermal stability and studied their structure in solution by using NMR and molecular dynamics. The solution structure of a fucose-TBA conjugate shows stacking interactions between the carbohydrate and the DNA G-tetrad in addition to hydrogen bonding and hydrophobic contacts. We have also shown that attaching carbohydrates at the 5′-end of a quadruplex telomeric sequence can alter its folding topology. These results suggest the possibility of modulating the folding of the G-quadruplex by linking carbohydrates and have clear implications in molecular recognition and the design of new G-quadruplex ligands. | es |
dc.description.sponsorship | Ministerio de Ciencia, Innovación y Universidades CTQ2009–13705, CTQ2010–20451, CTQ2010–21567-C02–02 | es |
dc.description.sponsorship | European Union MP0802 | es |
dc.description.sponsorship | Generalitat de Catalunya 2009/SGR/208 | es |
dc.description.sponsorship | Instituto de Salud Carlos III CB06 01 0019 | es |
dc.format | application/pdf | es |
dc.format.extent | 8 p. | es |
dc.language.iso | eng | es |
dc.publisher | Wiley-Blackwell | es |
dc.relation.ispartof | Chemistry - A European Journal, 19 (6), 1920-1927. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Carbohydrates | es |
dc.subject | DNA | es |
dc.subject | G-quadruplexes | es |
dc.subject | Hydrogen bonds | es |
dc.subject | Molecular interactions | es |
dc.subject | Stacking | es |
dc.title | Carbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-End | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica | es |
dc.relation.projectID | CTQ2009–13705 | es |
dc.relation.projectID | CTQ2010–20451 | es |
dc.relation.projectID | CTQ2010–21567-C02–02 | es |
dc.relation.projectID | MP0802 | es |
dc.relation.projectID | 2009/SGR/208 | es |
dc.relation.projectID | CB06 01 0019 | es |
dc.relation.publisherversion | https://doi.org/10.1002/chem.201203902 | es |
dc.identifier.doi | 10.1002/chem.201203902 | es |
dc.journaltitle | Chemistry - A European Journal | es |
dc.publication.volumen | 19 | es |
dc.publication.issue | 6 | es |
dc.publication.initialPage | 1920 | es |
dc.publication.endPage | 1927 | es |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (MICINN). España | es |
dc.contributor.funder | European Union (UE) | es |
dc.contributor.funder | Generalitat de Catalunya | es |
dc.contributor.funder | Instituto de Salud Carlos III | es |