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dc.creatorGómez Pinto, Irenees
dc.creatorVengut Climent, Empares
dc.creatorLucas Rodríguez, Ricardoes
dc.creatorAviñó, Annaes
dc.creatorEritja, Ramónes
dc.creatorGonzález, Carloses
dc.creatorMorales, Juan Carloses
dc.date.accessioned2022-07-12T15:56:00Z
dc.date.available2022-07-12T15:56:00Z
dc.date.issued2013
dc.identifier.citationGómez Pinto, I., Vengut Climent, E., Lucas Rodríguez, R., Aviñó, A., Eritja, R., González, C. y Morales, J.C. (2013). Carbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-End. Chemistry - A European Journal, 19 (6), 1920-1927.
dc.identifier.issn0947-6539es
dc.identifier.issn1521-3765es
dc.identifier.urihttps://hdl.handle.net/11441/135278
dc.description.abstractQuadruplex DNA structures are attracting an enormous interest in many areas of chemistry, ranging from chemical biology, supramolecular chemistry to nanoscience. We have prepared carbohydrate-DNA conjugates containing the oligonucleotide sequences of G-quadruplexes (thrombin binding aptamer (TBA) and human telomere (TEL)), measured their thermal stability and studied their structure in solution by using NMR and molecular dynamics. The solution structure of a fucose-TBA conjugate shows stacking interactions between the carbohydrate and the DNA G-tetrad in addition to hydrogen bonding and hydrophobic contacts. We have also shown that attaching carbohydrates at the 5′-end of a quadruplex telomeric sequence can alter its folding topology. These results suggest the possibility of modulating the folding of the G-quadruplex by linking carbohydrates and have clear implications in molecular recognition and the design of new G-quadruplex ligands.es
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades CTQ2009–13705, CTQ2010–20451, CTQ2010–21567-C02–02es
dc.description.sponsorshipEuropean Union MP0802es
dc.description.sponsorshipGeneralitat de Catalunya 2009/SGR/208es
dc.description.sponsorshipInstituto de Salud Carlos III CB06 01 0019es
dc.formatapplication/pdfes
dc.format.extent8 p.es
dc.language.isoenges
dc.publisherWiley-Blackwelles
dc.relation.ispartofChemistry - A European Journal, 19 (6), 1920-1927.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCarbohydrateses
dc.subjectDNAes
dc.subjectG-quadruplexeses
dc.subjectHydrogen bondses
dc.subjectMolecular interactionses
dc.subjectStackinges
dc.titleCarbohydrate-DNA interactions at G-quadruplexes: Folding and stability changes by attaching sugars at the 5′-Endes
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/publishedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Orgánica y Farmacéuticaes
dc.relation.projectIDCTQ2009–13705es
dc.relation.projectIDCTQ2010–20451es
dc.relation.projectIDCTQ2010–21567-C02–02es
dc.relation.projectIDMP0802es
dc.relation.projectID2009/SGR/208es
dc.relation.projectIDCB06 01 0019es
dc.relation.publisherversionhttps://doi.org/10.1002/chem.201203902es
dc.identifier.doi10.1002/chem.201203902es
dc.journaltitleChemistry - A European Journales
dc.publication.volumen19es
dc.publication.issue6es
dc.publication.initialPage1920es
dc.publication.endPage1927es
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (MICINN). Españaes
dc.contributor.funderEuropean Union (UE)es
dc.contributor.funderGeneralitat de Catalunyaes
dc.contributor.funderInstituto de Salud Carlos IIIes

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