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dc.creatorAtzeri, Angelaes
dc.creatorLucas Rodríguez, Ricardoes
dc.creatorIncani, Alessandraes
dc.creatorPeñalver, Pabloes
dc.creatorZafra-Gómez, Albertoes
dc.creatorMelis, M. Paolaes
dc.creatorPizzala, Robertoes
dc.creatorMorales, Juan C.es
dc.creatorDeiana, Monicaes
dc.date.accessioned2022-07-11T16:36:35Z
dc.date.available2022-07-11T16:36:35Z
dc.date.issued2016
dc.identifier.citationAtzeri, A., Lucas Rodríguez, R., Incani, A., Peñalver, P., Zafra-Gómez, A., Melis, M.P.,...,Deiana, M. (2016). Hydroxytyrosol and tyrosol sulfate metabolites protect against the oxidized cholesterol pro-oxidant effect in Caco-2 human enterocyte-like cells. Food and Function, 7 (1), 337-346.
dc.identifier.issn2042-6496es
dc.identifier.issn2042-650Xes
dc.identifier.urihttps://hdl.handle.net/11441/135229
dc.description.abstractThe aim of this study was to investigate the ability of the sulfate metabolites of hydroxytyrosol (HT) and tyrosol (TYR) to act as antioxidants counteracting the pro-oxidant effect of oxidized cholesterol in intestinal cells. For this purpose, we synthesized sulfate metabolites of HT and TYR using a chemical methodology and examined their antioxidant activity in Caco-2 monolayers in comparison with the parent compounds. Exposure to oxidized cholesterol led to ROS production, oxidative damage, as indicated by the MDA increase, a decrease of reduced glutathione concentration and an enhancement of glutathione peroxidase activity. All the tested compounds were able to counteract the oxidizing action of oxidized cholesterol; HT and TYR sulfate metabolites showed an efficiency in protecting intestinal cells comparable to that of the parent compounds, strengthening the assumption that the potential beneficial effect of the parent compounds is retained, although extensive metabolisation occurs, the resulting metabolites being able to exert a biological action themselves.es
dc.description.sponsorshipRegione Autonoma della Sardegna LR7- CRP-25300es
dc.description.sponsorshipJunta de Andalucía CVI-5007es
dc.formatapplication/pdfes
dc.format.extent15 p.es
dc.language.isoenges
dc.publisherRoyal Society of Chemistryes
dc.relation.ispartofFood and Function, 7 (1), 337-346.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleHydroxytyrosol and tyrosol sulfate metabolites protect against the oxidized cholesterol pro-oxidant effect in Caco-2 human enterocyte-like cellses
dc.typeinfo:eu-repo/semantics/articlees
dcterms.identifierhttps://ror.org/03yxnpp24
dc.type.versioninfo:eu-repo/semantics/acceptedVersiones
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.contributor.affiliationUniversidad de Sevilla. Departamento de Química Orgánica y Farmacéuticaes
dc.relation.projectIDLR7- CRP-25300es
dc.relation.projectIDCVI-5007es
dc.relation.publisherversionhttps://doi.org/10.1039/C5FO00074Bes
dc.identifier.doi10.1039/C5FO00074Bes
dc.journaltitleFood and Functiones
dc.publication.volumen7es
dc.publication.issue1es
dc.publication.initialPage337es
dc.publication.endPage346es
dc.contributor.funderRegione Autonoma della Sardegna. Italiaes
dc.contributor.funderJunta de Andalucíaes

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