Artículo
Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives
Autor/es | López Jiménez, Auxiliadora
Gallardo Morillo, Elena Espartero Sánchez, José Luis Madrona Mojarro, Andrés Quesada, Ana R. Medina, Miguel Ángel |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica |
Fecha de publicación | 2018 |
Fecha de depósito | 2022-07-06 |
Publicado en |
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Resumen | Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously ... Hydroxytyrosol is a phenolic compound present in extra virgin olive oil, either in free form or as derivatives, and related to some of the health benefits described for olive oil intake. We have demonstrated previously that hydroxytyrosol inhibits angiogenesis both in vitro and in vivo. In the present study, we evaluate the anti-angiogenic potential of five hydroxytyrosol derivatives. Three of these derivatives contain a nitro group and they exhibit a much weaker effect than hydroxytyrosol in the tubule formation assay on Matrigel and therefore were not studied further. In contrast, both hydroxytyrosyl acetate and ethyl hydroxytyrosyl ether show more potent inhibitory effects than hydroxytyrosol in both the in vitro tubule formation assay on Matrigel and the in vivo chorioallantoic membrane assay. Additionally, these three compounds had slight pro-apoptotic effects and decreased matrix metalloproteinase-2 levels in cell extracts. |
Agencias financiadoras | Ministerio de Economía y Competitividad (MINECO). España Junta de Andalucía |
Identificador del proyecto | BIO2014-56092-R
P12-CTS-1507 P09-AGR-5098 |
Cita | López Jiménez, A., Gallardo Morillo, E., Espartero Sánchez, J.L., Madrona Mojarro, A., Quesada, A.R. y Medina, M.Á. (2018). Comparison of the anti-angiogenic potential of hydroxytyrosol and five derivatives. Food and Function, 9 (8), 4310-4316. |
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