Artículo
A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers
Autor/es | Marrero, Ana Dácil
Castilla, Laura Espartero Sánchez, José Luis Madrona, Andrés R. Quesada, Ana Medina, Miguel Ángel Martínez Poveda, Beatriz |
Departamento | Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica |
Fecha de publicación | 2020 |
Fecha de depósito | 2022-07-05 |
Publicado en |
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Resumen | The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the antiangiogenic ... The phenolic compound hydroxytyrosol and its derivatives are responsible for some of the health benefits of the intake of virgin olive oil, having shown antiangiogenic properties. In this study, we explored the antiangiogenic potential of six synthetic hydroxytyrosyl alkyl ethers (HT C1, C2, C4, C6, C8 and C12). Our results showed that all compounds affected endothelial cell viability in vitro at low micromolar doses. In addition, compounds HT C1, C2, C4 and C6 inhibited endothelial cell migration and formation of tubular-like structures. In these assays, hydroxytyrosyl hexyl ether (HT C6) exhibited the most potent inhibitory activity in vitro, activating as well apoptosis in endothelial cells. Furthermore, the antiangiogenic activity of HT C6 was confirmed in vivo in the chick chorioallantoic membrane assay. Hence, we present hydroxytyrosol synthetic derivative HT C6 as a new antiangiogenic compound and as a good candidate for an antiangiogenic drug in the treatment of angiogenesis-dependent diseases. |
Agencias financiadoras | Ministerio de Ciencia, Innovación y Universidades (MICINN). España Junta de Andalucía |
Identificador del proyecto | AGL2007-66373
PID2019-105010RB-I00 P12-CTS-1507 UMA18-FEDERJA-220 |
Cita | Marrero, A.D., Castilla, L., Espartero Sánchez, J.L., Madrona, A., R. Quesada, A., Medina, M.Á. y Martínez Poveda, B. (2020). A comparative study of the antiangiogenic activity of hydroxytyrosyl alkyl ethers. Food Chemistry, 333, 127476. |
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