dc.creator | Castellanos Gil, Eddy | es |
dc.creator | Iraizoz Colarte, Antonio | es |
dc.creator | Bataille, Bernard | es |
dc.creator | Brouillet, Fabien | es |
dc.creator | Caraballo Rodríguez, Isidoro | es |
dc.date.accessioned | 2022-06-10T14:32:08Z | |
dc.date.available | 2022-06-10T14:32:08Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Castellanos Gil, E., Iraizoz Colarte, A., Bataille, B., Brouillet, F. y Caraballo Rodríguez, I. (2009). Estimation of the percolation thresholds in ternary lobenzarit disodium-dextran-HPMC hydrophilic matrices tablets: Effects of initial porosity. European Journal of Pharmaceutical Sciences, 38 (4), 312-319. | |
dc.identifier.issn | 0928-0987 | es |
dc.identifier.issn | 1879-0720 | es |
dc.identifier.uri | https://hdl.handle.net/11441/134289 | |
dc.description.abstract | The aim of this work is to estimate the excipient percolation threshold for a new combined matrix native dextran (DT), series B110-1-2 (Mw 2 × 106): HPMC K4M CR: lobenzarit disodium (LBD) system and demonstrate the advantages of this ternary system with respect to previously reported binary dextran:LBD and HPMC:LBD tablets. The formulations studied were prepared with different amounts of excipient (DT:HPMC, 4:1 (wt/wt) for all tablets and relative polymer/drug particle size of 4.17) in the range of 10-70% (wt/wt). Dissolution studies were carried out using the paddle method (100 rpm) and one face water uptake measurements were performed using a modified Enslin apparatus. The Higuchi's models as well as the non-linear regression were employed as empiric methods to study the released data. Values of diffusion exponent 0.588 < n < 0.784 (Korsmeyer equation) for dissolution profile and water uptake mechanism 0.715 < n < 0.960 (Davidson and Peppas equation) suggests anomalous or complex mechanisms in all cases. The critical points in ternary tablets were reduced from 44.75% (v/v) of excipient (correspond to purely native dextran) to 22.34% (v/v) (corresponding to mixture native dextran:HPMC, 4:1, wt/wt). The initial porosity (IP) of hydrophilic matrices above the values of 20% has an important influence on the percolation threshold as well as on establishment of the gel barrier responsible for the controlled release from the DT:HPMC:LBD tablets. | es |
dc.description.sponsorship | European Union E05D055758CU | es |
dc.format | application/pdf | es |
dc.format.extent | 10 p. | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | European Journal of Pharmaceutical Sciences, 38 (4), 312-319. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | HPMC | es |
dc.subject | Hydrophilic matrices | es |
dc.subject | Initial porosity | es |
dc.subject | Lobenzarit disodium | es |
dc.subject | Native dextran | es |
dc.subject | Percolation threshold | es |
dc.subject | Ternary system | es |
dc.title | Estimation of the percolation thresholds in ternary lobenzarit disodium-dextran-HPMC hydrophilic matrices tablets: Effects of initial porosity | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Farmacia y Tecnología Farmacéutica | es |
dc.relation.projectID | E05D055758CU | es |
dc.relation.publisherversion | https://doi.org/10.1016/j.ejps.2009.07.013 | es |
dc.identifier.doi | 10.1016/j.ejps.2009.07.013 | es |
dc.journaltitle | European Journal of Pharmaceutical Sciences | es |
dc.publication.volumen | 38 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 312 | es |
dc.publication.endPage | 319 | es |
dc.contributor.funder | European Union (UE) | es |