Ponencia
Biclustering of Gene Expression Data Based on SimUI Semantic Similarity Measure
Autor/es | Nepomuceno Chamorro, Juan Antonio
![]() ![]() ![]() ![]() ![]() ![]() ![]() Troncoso Lora, Alicia Nepomuceno Chamorro, Isabel de los Ángeles ![]() ![]() ![]() ![]() ![]() ![]() ![]() Aguilar Ruiz, Jesús Salvador |
Departamento | Universidad de Sevilla. Departamento de Lenguajes y Sistemas Informáticos |
Fecha de publicación | 2016 |
Fecha de depósito | 2022-04-25 |
Publicado en |
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ISBN/ISSN | 978-3-319-32033-5 0302-9743 |
Resumen | Biclustering is an unsupervised machine learning technique
that simultaneously clusters genes and conditions in gene expression
data. Gene Ontology (GO) is usually used in this context to validate
the biological relevance ... Biclustering is an unsupervised machine learning technique that simultaneously clusters genes and conditions in gene expression data. Gene Ontology (GO) is usually used in this context to validate the biological relevance of the results. However, although the integration of biological information from different sources is one of the research directions in Bioinformatics, GO is not used in biclustering as an input data. A scatter search-based algorithm that integrates GO information during the biclustering search process is presented in this paper. SimUI is a GO semantic similarity measure that defines a distance between two genes. The algorithm optimizes a fitness function that uses SimUI to integrate the biological information stored in GO. Experimental results analyze the effect of integration of the biological information through this measure. A SimUI fitness function configuration is experimentally studied in a scatter search-based biclustering algorithm |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Junta de Andalucía Universidad Pablo de Olavide |
Identificador del proyecto | TIN2011-28956-C02-02
![]() TIN2014-55894-C2-R ![]() P12-TIC-1728 ![]() APPB813097 ![]() |
Cita | Nepomuceno Chamorro, J.A., Troncoso Lora, A., Nepomuceno Chamorro, I.d.l.Á. y Aguilar Ruiz, J.S. (2016). Biclustering of Gene Expression Data Based on SimUI Semantic Similarity Measure. En HAIS 2016 : 11th International Conference on Hybrid Artificial Intelligence Systems (685-693), Sevilla, España: Springer. |
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