Artículo
Nitric oxide synthesis by nitrate reductase is regulated during development in Aspergillus
Autor/es | Marcos Rodríguez, Ana Teresa
Ramos Guelfo, María Salud Marcos, José F. Carmona, Lourdes Strauss, Joseph Cánovas López, David |
Departamento | Universidad de Sevilla. Departamento de Genética |
Fecha de publicación | 2016 |
Fecha de depósito | 2022-03-22 |
Publicado en |
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Resumen | Nitric oxide (NO) is a signalling molecule involved in many biological processes in bacteria, plants and mammals. However, little is known about the role and biosynthesis of NO in fungi. Here we show that NO production is ... Nitric oxide (NO) is a signalling molecule involved in many biological processes in bacteria, plants and mammals. However, little is known about the role and biosynthesis of NO in fungi. Here we show that NO production is increased at the early stages of the transition from vegetative growth to development in Aspergillus nidulans. Full NO production requires a functional nitrate reductase (NR) gene (niaD) that is upregulated upon induction of conidiation, even under N-repressing conditions in the presence of ammonium. At this stage, NO homeostasis is achieved by balancing biosynthesis (NR) and catabolism (flavohaemoglobins). niaD and flavohaemoglobin fhbA are transiently upregulated upon induction of conidiation, and both regulators AreA and NirA are necessary for this transcriptional response. The second flavohaemoglobin gene fhbB shows a different expression profile being moderately expressed during the early stages of the transition phase from vegetative growth to conidiation, but it is strongly induced 24 h later. NO levels influence the balance between conidiation and sexual reproduction because artificial strong elevation of NO levels reduced conidiation and induced the formation of cleistothecia. The nitrate-independent and nitrogen metabolite repression-insensitive transcriptional upregulation of niaD during conidiation suggests a novel role for NR in linking metabolism and development. |
Agencias financiadoras | Ministerio de Economia, Industria y Competitividad (MINECO). España Lower Austria Science Fund Austrian Science Fund (FWF) |
Identificador del proyecto | BIO2012-34381
LS12-009 M01693-B22 |
Cita | Marcos Rodríguez, A.T., Ramos Guelfo, M.S., Marcos, J.F., Carmona, L., Strauss, J. y Cánovas López, D. (2016). Nitric oxide synthesis by nitrate reductase is regulated during development in Aspergillus. Molecular Microbiology, 99 (1), 15-33. |
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