dc.creator | Begines Aguilar, Paloma | es |
dc.creator | Martos Delgado, Sergio | es |
dc.creator | Lagunes, Irene | es |
dc.creator | Maya Castilla, Inés | es |
dc.creator | Padrón, José M. | es |
dc.creator | López López, Óscar | es |
dc.creator | Fernández-Bolaños Guzmán, José María | es |
dc.date.accessioned | 2022-03-04T16:41:45Z | |
dc.date.available | 2022-03-04T16:41:45Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Begines Aguilar, P., Martos Delgado, S., Lagunes, I., Maya Castilla, I., Padrón, J.M., López López, Ó. y Fernández-Bolaños Guzmán, J.M. (2022). Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment. Molecules, 27 (4), 1315. | |
dc.identifier.issn | 1420-3049 | es |
dc.identifier.uri | https://hdl.handle.net/11441/130409 | |
dc.description.abstract | Being aware of the enormous biological potential of organoselenium and polyphenolic compounds, we have accomplished the preparation of novel hybrids, combining both pharma-cophores in order to obtain new antioxidant and antiproliferative agents. Three different families have been accessed in a straightforward and chemoselective fashion: carbohydrate-containing N-acylisoselenoureas, N-arylisoselenocarbamates and N-arylselenocarbamates. The nature of the organoselenium framework, number and position of phenolic hydroxyl groups and substituents on the aromatic scaffolds afforded valuable structure–activity relationships for the biological as-says accomplished: antioxidant properties (antiradical activity, DNA-protective effects, Glutathione peroxidase (GPx) mimicry) and antiproliferative activity. Regarding the antioxidant activity, selenocar-bamates 24–27 behaved as excellent mimetics of GPx in the substoichiometric elimination of H2O2 as a Reactive Oxygen Species (ROS) model. Isoselenocarbamates and particularly their selenocarbamate isomers exhibited potent antiproliferative activity against non-small lung cell lines (A549, SW1573) in the low micromolar range, with similar potency to that shown by the chemotherapeutic agent cisplatin (cis-diaminodichloroplatin, CDDP) and occasionally with more potency than etoposide (VP-16). | es |
dc.description.sponsorship | Ministerio de Ciencia e Innovación PID2020-116460RB-I00 | es |
dc.description.sponsorship | Junta de Andalucía FQM134 | es |
dc.description.sponsorship | Gobierno de las Islas Canarias ProID2020010101 | es |
dc.format | application/pdf | es |
dc.format.extent | 19 p. | es |
dc.language.iso | eng | es |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es |
dc.relation.ispartof | Molecules, 27 (4), 1315. | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Antioxidant | es |
dc.subject | Antiproliferative agents | es |
dc.subject | GPx mimetic | es |
dc.subject | Isoselenocarbamates | es |
dc.subject | Isoselenoureas | es |
dc.subject | Organoselenium | es |
dc.subject | Polyphenols | es |
dc.subject | Selenocarbamates | es |
dc.title | Chemoselective Preparation of New Families of Phenolic-Organoselenium Hybrids—A Biological Assessment | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Química orgánica | es |
dc.relation.projectID | PID2020-116460RB-I00 | es |
dc.relation.projectID | FQM134 | es |
dc.relation.projectID | ProID2020010101 | es |
dc.relation.publisherversion | https://doi.org/10.3390/molecules27041315 | es |
dc.identifier.doi | 10.3390/molecules27041315 | es |
dc.journaltitle | Molecules | es |
dc.publication.volumen | 27 | es |
dc.publication.issue | 4 | es |
dc.publication.initialPage | 1315 | es |