Artículo
Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation
Autor/es | Trompier, François
Baumann, Marion Barrios, Lleonard Gregoire, Eric Abend, Michael Ainsbury, Elizabeth Domínguez García, Inmaculada Mateos Pérez, Juan Carlos Roy, Laurence |
Departamento | Universidad de Sevilla. Departamento de Biología Celular |
Fecha de publicación | 2017 |
Fecha de depósito | 2022-02-11 |
Publicado en |
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Resumen | Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols ... Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiation practices in the European biological dosimetry network. Materials and methods: Delivered doses by irradiation facilities used by RENEB partners were determined with EPR/alanine dosimetry system. Dosimeters were irradiated in the same conditions as blood samples. A short survey was also performed to collect the information needed for the data analysis and evaluate the diversity of practices. Results: For most of partners the deviation of delivered dose from the targeted dose remains below 10%. Deviations larger than 10% were observed for five facilities out of 21. Origins of the largest discrepancies were identified. Correction actions were evaluated as satisfactory. The re-evaluation of some ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC) assays has been performed leading to an improvement of the overall performances. Conclusions: This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation. |
Agencias financiadoras | European Commission (EC) |
Identificador del proyecto | 295513 |
Cita | Trompier, F., Baumann, M., Barrios, L., Gregoire, E., Abend, M., Ainsbury, E.,...,Roy, L. (2017). Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation. International Journal of Radiation Biology, 93 (1), 118-126. |
Ficheros | Tamaño | Formato | Ver | Descripción |
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10.1080_09553002.2016.1213455.pdf | 2.285Mb | [PDF] | Ver/ | |