Genética
Recent Submissions
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PhD Thesis
Molecular basis of Aicardi-Goutières syndrome
(2023-09-21)DNA is an essential molecule for the proper functioning of the cell that is constantly exposed to exogenous and endogenous ...
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PhD Thesis
Genome Instability Associated with DNA Topoisomerase Activity during Gene Transcription
(2023-07-07)Las lesiones que se producen en el ADN suponen un desafío continuo para la integridad genómica, siendo las roturas de ...
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PhD Thesis
Activity of the CarS RING finger protein and regulatory connections with CwhA and HmbC in Fusarium fujikuroi
(2023-07-25)The genus Fusarium is a heterogeneous group of phytopathogenic fungi that causes diseases in a large diversity of economically ...
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PhD Thesis
Unraveling the connection between centrosomes and the DNA damage response
(2023-06-20)Centrosomes act as the major microtubule (MT) organizing centers (MTOC) in most animal cells. Structural or numerical defects in this organelle are associated with ...
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PhD Thesis
Molecular description of the role of protein synthesis in the cellular response to the treatment with the antitumoral drug Sorafenib in HCC lines
(2023-06-07)El carcinoma hepatocellular (CHC) es reconocido como el principal cáncer primario de hígado y uno de los cánceres con ...
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PhD Thesis
Non-canonical DNA structures in Double Strand Break repair
(2023-05-22)DNA double-strand breaks (DSBs) pose a serious threat to genome stability, so their proper repair is crucial for cell ...
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PhD Thesis
eL15 and eL22 proteins and their functional environments during ribosome assembly in Saccharomyces cerevisiae
(2023-05-18)Ribosomes are ribonucleoprotein complexes in charge of protein translation. Translation is an essential process in all ...
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PhD Thesis
Molecular bases of proliferative heterogeneity in Saccharomyces cerevisiae
(2023-05-11)Proliferative heterogeneity has been widely described in clonal cultures, but the mechanisms underlying this phenomenon ...
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PhD Thesis
Insights into RNA-mediated genome instability by altering ALY expression and the use of new drugs
(2023-04-12)Las células han desarrollado una serie de mecanismos que utilizan de forma coordinada para mantener la integridad del ...
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PhD Thesis
Transcriptional regulation by the Velvet complex during development in Neurospora crassa
(2023-04-21)Developmental transitions in fungi are key to their success in colonizing new habitats and adapting to stressful environmental ...
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PhD Thesis
Contribución de la ruta de reparación del ADN Anemia de Fanconi al mantenimiento de la estabilidad de la horquilla de replicación durante la incorporación de desoxirribonucleótidos hidroximetilados
(2023-02-16)El genoma está constantemente expuesto a agentes tanto endógenos como exógenos que amenazan la integridad del mismo. Es ...
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PhD Thesis
Descripción y caracterización de la interacción física entre los complejos MCM y RNR en respuesta a daños en el ADN
(2022-05-24)El complejo MCM junto con el factor Cdc45 y el complejo GINS forman la helicasa replicativa en eucariotas, cuya actividad ...
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PhD Thesis
Identificación y análisis funcional del lnc-Nr6a1 y del mRNA Serpine1 como reguladores tempranos de la transición epitelio-mesénquima
(2022-05-12)La transición epitelio-mesénquima (EMT) es un proceso por el que las células sufren un cambio fenotípico reversible, ...
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PhD Thesis
Global Dynamics of Topoisomerase II Activity
(2022-04-22)DNA topoisomerases are key enzymes in charge of solving topological problems that arise from essential processes of DNA ...
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PhD Thesis
DDX47 and MECP2, two novel human functions controlling R-loop-mediated genome integrity
(2021-10-28)La integridad del genoma es un requisito indispensable para la correcta transmisión de la información genética de una ...
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PhD Thesis
Implicaciones biológicas de las interacciones con proteínas del hospedador de SseK1 y SlrP, dos efectores de los sistemas de secreción tipo III de Salmonella
(2021-10-20)Salmonella enterica es una especie de bacteria patógena Gram negativa que puede producir diferentes enfermedades, desde ...
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PhD Thesis
Regulatory roles of photoreceptors and non-coding RNA in Fusarium fujikuroi
(2021-05-20)The genus Fusarium comprises hundreds of species of pathogenic and saprophytic fungi, usually characterized by a complex ...
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PhD Thesis
Identification and Characterization of Factors Involved in Sodium Selenite Toxicity
(2021-07-06)Selenium (Se) is an essential micronutrient in many organisms. Despite being essential for some organisms, the range between ...
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PhD Thesis
Influence of chromatin factors and DNA-RNA hybrids in the repair of replication-born DSBs
(2021-06-02)La información genética debe estar almacenada de manera segura en la molécula de ADN. Sin embargo, el ADN está continuamente ...
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PhD Thesis
Identificación y caracterización de elementos regulatorios distales controlados por TGFβ
(2021-03-02)En este trabajo se ha realizado un análisis exhaustivo de los enhancers en células normales de epitelio de glándula mamaria ...