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Mostrando ítems 1-10 de 20
Artículo
Spatio-temporal simulations of bone remodelling using a bone cell population model based on cell availability
(Frontiers, 2023)
Here we developed a spatio-temporal bone remodeling model to simulate the action of Basic Multicelluar Units (BMUs). This model is based on two major extensions of a temporal-only bone cell population model (BCPM). First, ...
Artículo
Mechanistic PK-PD model of alendronate treatment of postmenopausal osteoporosis predicts bone site-specific response
(Frontiers Media S.A., 2022-08-17)
Alendronate is the most widely used drug for postmenopausal osteoporosis (PMO). It inhibits bone resorption, affecting osteoclasts. Pharmacokinetics (PK) and pharmacodynamics (PD) of alendronate have been widely studied, ...
Artículo
Experimental study on the fretting fatigue of Inconel 718 superalloy
(Elsevier, 2023)
Fretting fatigue is a surface damage phenomenon appearing in mechanical assemblies subjected to time-varying contact forces. This type of failure is a very frequent problem in many engineering components, with special relevance ...
Artículo
The effect of kinematic constraints in the inverse dynamics problem in biomechanics
(Springer, 2016)
The inverse dynamics is a classic problem to be solved in gait analysis. The solution is the vector of joint reactions and driving actions which is essential to perform a kinetic analysis of the human gait. Multibody system ...
Ponencia
Experimental Study on the Evaluation of Necking and Fracture Strains in Sheet Metal Forming Processes
(Elsevier, 2013)
In this paper the formability of AA2024-T3 metal sheets is experimentally analyzed. For this purpose, a series of StretchBending and Incremental Sheet Forming (ISF) tests are carried out. The former tests allow determine ...
Artículo
Implementation of synthetic fast-ion loss detector and imaging heavy ion beam probe diagnostics in the 3D hybrid kinetic-MHD code MEGA
(American Institute of Physics, 2021-04-27)
A synthetic fast-ion loss (FIL) detector and an imaging Heavy Ion Beam Probe (i-HIBP) have been implemented in the 3D hybrid kinetic-magnetohydrodynamic code MEGA. First synthetic measurements from these two diagnostics ...
Artículo
Are drug holidays a safe option in treatment of osteoporosis? — Insights from an in silico mechanistic PK–PD model of denosumab treatment of postmenopausal osteoporosis
(Elsevier, 2021-01)
Recent reviews by the clinical bone research community suggest caution with prescription of drug holidays for patients with postmenopausal osteoporosis (PMO) treated with denosumab for an extended period of time. Main ...
Artículo
Experimental investigation of polycarbonate sheets deformed by SPIF: formability, micro-mechanisms of failure and temperature analysis
(Elsevier, 2023)
This article presents an experimental research performed on a polycarbonate sheet deformed by single point incremental forming (SPIF). The analysis is implemented within the framework developed in previous research work ...
Artículo
Averaging material tensors of any rank in textured polycrystalline materials: Extending the scope beyond crystallographic proper point groups
(Elsevier, 2023-12)
In many modern micromechanical applications, there is usually a need to perform the orientational averaging of certain material tensors weighted by an orientation distribution function (ODF). The computation of these ...
Artículo
Mechanics Predicts Effective Critical-Size Bone Regeneration Using 3D-Printed Bioceramic Scaffolds
(Springer, 2023)
BACKGROUND: 3D-printed bioceramic scaffolds have gained popularity due to their controlled microarchitecture and their proven biocompatibility. However, their high brittleness makes their surgical implementation complex ...