dc.creator | Hoys Hernández, Cristina | es |
dc.creator | Romero Losada, Ana Belén | es |
dc.creator | Río, Esperanza del | es |
dc.creator | Guerrero, Miguel G. | es |
dc.creator | Romero Campero, Francisco José | es |
dc.creator | García González, Mercedes | es |
dc.date.accessioned | 2021-05-31T10:45:28Z | |
dc.date.available | 2021-05-31T10:45:28Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Hoys Hernández, C., Romero Losada, A.B., Río, E.d., Guerrero, M.G., Romero Campero, F.J. y García González, M. (2021). Unveiling the underlying molecular basis of astaxanthin accumulation in Haematococcus through integrative metabolomic-transcriptomic analysis. Bioresource Technology, 332 (July 2021) | |
dc.identifier.issn | 0960-8524 | es |
dc.identifier.uri | https://hdl.handle.net/11441/111226 | |
dc.description.abstract | Astaxanthin is a valuable and highly demanded ketocarotenoid pigment, for which the chlorophycean microalga
Haematococcus pluvialis is an outstanding natural source. Although information on astaxanthin accumulation in
H. pluvialis has substantially advanced in recent years, its underlying molecular bases remain elusive. An integrative
metabolic and transcriptomic analysis has been performed for vegetative Haematococcus cells, grown
both under N sufficiency (green palmelloid cells) and under moderate N limitation, allowing concurrent active
cell growth and astaxanthin synthesis (reddish palmelloid cells). Transcriptional activation was noticeable in
reddish cells of key enzymes participating in glycolysis, pentose phosphate cycle and pyruvate metabolism,
determining the adequate provision of glyceraldehyde 3 phosphate and pyruvate, precursors of carotenoids and
fatty acids. Moreover, for the first time, transcriptional regulators potentially involved in controlling astaxanthin
accumulation have been identified, a knowledge enabling optimization of commercial astaxanthin production by
Haematococcus through systems metabolic engineering. | es |
dc.description.sponsorship | Ministerio de Economía y Competitividad BIO2017-84066-R | es |
dc.format | application/pdf | es |
dc.format.extent | 11 | es |
dc.language.iso | eng | es |
dc.publisher | Elsevier | es |
dc.relation.ispartof | Bioresource Technology, 332 (July 2021) | |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Astaxanthin | es |
dc.subject | Carotenogenesis | es |
dc.subject | H. pluvialis | es |
dc.subject | Transcriptome sequencing | es |
dc.subject | Metabolic pathways | es |
dc.title | Unveiling the underlying molecular basis of astaxanthin accumulation in Haematococcus through integrative metabolomic-transcriptomic analysis | es |
dc.type | info:eu-repo/semantics/article | es |
dcterms.identifier | https://ror.org/03yxnpp24 | |
dc.type.version | info:eu-repo/semantics/submittedVersion | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Ciencias de la Computación e Inteligencia Artificial | es |
dc.contributor.affiliation | Universidad de Sevilla. Departamento de Bioquímica Vegetal y Biología Molecular | |
dc.relation.projectID | BIO2017-84066-R | es |
dc.relation.publisherversion | https://www.sciencedirect.com/science/article/pii/S0960852421004892?via%3Dihub | es |
dc.identifier.doi | 10.1016/j.biortech.2021.125150 | es |
dc.journaltitle | Bioresource Technology | es |
dc.publication.volumen | 332 | es |
dc.publication.issue | July 2021 | es |
dc.contributor.funder | Ministerio de Economía y Competitividad (MINECO). España | es |