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Artículo
Aberrant cortical associative plasticity associated with severe adult Tourette syndrome
(Wiley, 2015)
Background. Recent studies have shown altered cortical plasticity in adult patients with Tourette syndrome. However, the clinical significance of this finding remains elusive. Methods. Motor cortical plasticity was evaluated ...
Artículo
European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents
(Springer Berlin Heidelberg, 2018-07-07)
Genetic predisposition, autoimmunity and environmental factors [e.g. pre- and perinatal difficulties, Group A Streptococcal (GAS) and other infections, stress-inducing events] might interact to create a neurobiological ...
Artículo
Quantitative Intensity Harmonization of Dopamine Transporter SPECT Images Using Gamma Mixture Models
(Springer, 2018-07-09)
PURPOSE: Differences in site, device, and/or settings may cause large variations in the intensity profile of dopamine transporter (DAT) single-photon emission computed tomography (SPECT) images. However, the current ...
Artículo
The social impact of Parkinson’s disease in Spain: Report by the Spanish Foundation for the Brain
(Elsevier, 2016)
Introduction: Understanding the social and economic impact of Parkinson’s disease is essential for resource planning and raising social awareness. Development: Researchers reviewed the data published to date on epidemiology, ...
Artículo
Effects of Two Weeks of Cerebellar Theta Burst Stimulation in Cervical Dystonia Patients
(Elsevier, 2014)
Dystonia is generally regarded as a disorder of the basal ganglia and their efferent connections to the thalamus and brainstem, but an important role of cerebellar-thalamo-cortical (CTC) circuits in the pathophysiology ...
Artículo
Genetic factors influencing frontostriatal dysfunction and the development of dementia in Parkinson's disease
(Public Library of Science, 2017)
The dual syndrome hypothesis for cognitive impairment in Parkinson's disease (PD) establishes a dichotomy between a frontrostriatal dopamine-mediated syndrome, which leads to executive deficits, and a posterior cortical ...
Artículo
Parieto-motor Cortical Dysfunction in Primary Cervical Dystonia
(Elsevier, 2014)
Background: Dystonia is considered as a motor network disorder involving the dysfunction of the posterior parietal cortex, a region involved in preparing and executing reaching movements. Objective/hypothesis: We used ...
Artículo
GBA Variants Influence Motor and Non-Motor Features of Parkinson’s Disease.
(Public Library Of Science, 2016-12-28)
The presence of mutations in glucocerebrosidase (GBA) gene is a known factor increasing the risk of developing Parkinson’s disease (PD). Mutations carriers have earlier disease onset and are more likely to develop ...
Artículo
Tremor stability index: a new tool for differential diagnosis in tremor syndromes
(Oxford University Press, 2017)
Misdiagnosis among tremor syndromes is common, and can impact on both clinical care and research. To date no validated neurophysiological technique is available that has proven to have good classification performance, and ...
Artículo
Machine learning models for the differential diagnosis of vascular parkinsonism and Parkinson's disease using [(123)I]FP-CIT SPECT
(Springer, 2015)
Purpose: The study’s objective was to develop diagnostic predictive models using data from two commonly used [(123)I]FP-CIT SPECT assessment methods: region-of-interest (ROI) analysis and whole-brain voxel-based analysis. ...