Buscar
Mostrando ítems 1-10 de 28
Artículo
Late rDNA Condensation Ensures Timely Cdc14 Release and Coordination of Mitotic Exit Signaling with Nucleolar Segregation
(Elsevier, 2017)
The nucleolus plays a pivotal role in multiple key cellular processes. An illustrative example is the regulation of mitotic exit in Saccharomyces cerevisiae through the nucleolar sequestration of the Cdc14 phosphatase. The ...
Artículo
Analysis of the relationship between coexpression domains and chromatin 3D organization
(Public Library of Science, 2017)
Gene order is not random in eukaryotic chromosomes, and co-regulated genes tend to be clustered. The mechanisms that determine co-regulation of large regions of the genome and its connection with chromatin three-dimensional ...
Artículo
The need to regulate replication fork speed
(American Association for the Advancement of Science, 2017)
Artículo
Monoubiquitination of syntaxin 3 leads to retrieval from the basolateral plasma membrane and facilitates cargo recruitment to exosomes
(American Society for Cell Biology, 2017)
Syntaxin 3 (Stx3), a SNARE protein located and functioning at the apical plasma membrane of epithelial cells, is required for epithelial polarity. A fraction of Stx3 is localized to late endosomes/lysosomes, although how ...
Artículo
DNA-RNA hybrids: The risks of DNA breakage during transcription
(Springer Nature, 2017)
Although R loops can occur at different genomic locations, the factors that determine their formation and frequency remain unclear. Emerging evidence indicates that DNA breaks stimulate DNA-RNA hybrid formation. Here, we ...
Artículo
Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer
(Impact Journals, 2017)
Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We wished to identify new therapeutic targets for ovarian cancer. ShRNA screen performed in 42 ovarian cancer cell lines identified the ...
Artículo
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme
(Nature Publishing Group, 2017)
Mutations in chromatin modifier genes are frequently associated with neurodevelopmental diseases. We herein demonstrate that the chromodomain helicase DNA-binding protein 7 (Chd7), frequently associated with CHARGE syndrome, ...
Artículo
Generation of a Vero-Based Packaging Cell Line to Produce SV40 Gene Delivery Vectors for Use in Clinical Gene Therapy Studies
(Elsevier, 2017)
Replication-defective (RD) recombinant simian virus 40 (SV40)-based gene delivery vectors hold a great potential for clinical applications because of their presumed non-immunogenicity and capacity to induce immune tolerance ...
Artículo
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
(Nature Publishing Group, 2017)
DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome instability and chromosome translocation. TOP2-induced DNA double-strand breaks are rejoined in part by ...
Artículo
Highly efficient neural conversion of human pluripotent stem cells in adherent and animal-free conditions
(Wiley, 2017)
Neural differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) can produce a valuable and robust source of human neural cell subtypes, holding great promise for the study of ...