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Artículo
Yra1-bound RNA–DNA hybrids cause orientation-independent transcription– replication collisions and telomere instability
(Cold Spring Harbor Laboratory Press, 2018)
R loops are an important source of genome instability, largely due to their negative impact on replication progression. Yra1/ALY is an abundant RNA-binding factor conserved from yeast to humans and required for mRNA export, ...
Artículo
Histone Mutants Separate R Loop Formation from Genome Instability Induction
(Elsevier, 2017)
R loops have positive physiological roles, but they can also be deleterious by causing genome instability, and the mechanisms for this are unknown. Here we identified yeast histone H3 and H4 mutations that facilitate R ...